Chromatin insulators: regulatory mechanisms and epigenetic inheritance.
Chromatin insulators: regulatory mechanisms and epigenetic inheritance.
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DOI：
10.1016/j.molcel.2008.08.017
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发表时间：
2008-10-10
期刊：
影响因子：
16
通讯作者：
Corces, Victor G.
中科院分区：
文献类型：
--
作者：
Bushey, Ashley M.;Dorman, Elizabeth R.;Corces, Victor G.
增强子阻断绝缘子是破坏调控序列（如增强子或沉默子）与启动子之间的通讯的DNA元件。绝缘子参与转录调控和整体核组织，这两个特征被认为是通过表观遗传机制从一代到下一代保持的染色质。此外，还有许多调节机制可以增强或阻碍绝缘子的活性。这些调节模式可用于建立沿着细胞和/或生物体谱系表观遗传地遗传的细胞类型特异性绝缘子活性。本文将讨论绝缘子功能的表观遗传和调控的证据。
Enhancer-blocking insulators are DNA elements that disrupt the communication between a regulatory sequence, such as an enhancer or a silencer, and a promoter. Insulators participate in both transcriptional regulation and global nuclear organization, two features of chromatin that are thought to be maintained from one generation to the next through epigenetic mechanisms. Furthermore, there are many regulatory mechanisms in place that enhance or hinder insulator activity. These modes of regulation could be used to establish cell-type specific insulator activity that is epigenetically inherited along a cell and/or organismal lineage. This review will discuss the evidence for epigenetic inheritance and regulation of insulator function.
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