Influence of Skeletal Muscle Carnosine Content on Fatigue during Repeated Resistance Exercise in Recreationally Active Women.
Influence of Skeletal Muscle Carnosine Content on Fatigue during Repeated Resistance Exercise in Recreationally Active Women.
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DOI：
10.3390/nu9090988
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发表时间：
2017-09-07
期刊：
影响因子：
5.9
通讯作者：
Stout JR
中科院分区：
文献类型：
--
作者：
Varanoske AN;Hoffman JR;Church DD;Wang R;Baker KM;Dodd SJ;Coker NA;Oliveira LP;Dawson VL;Fukuda DH;Stout JR
肌肽是一种天然存在的肌内二肽，被认为可以在高强度运动期间减轻疲劳。肌肽含量受多种因素影响，包括性别和饮食。尽管研究报告称，与男性相比，女性的肌肽含量较低，与杂食动物相比，素食者的肌肽含量较低，但没有研究基于膳食蛋白质摄入量及其对肌肉疲劳的影响来检查女性的肌肽含量。根据股外侧肌肌内肌肽含量，将20名娱乐活跃的女性分为高（HI; n = 5）、中（MOD; n = 10）或低（LO; n = 5）组。每个参与者进行了两个单侧最大自愿等长收缩（MVIC）的膝伸肌分开的等速运动协议组成的5组50个重复的最大单侧收缩。基于量值的推断被用来分析组间差异。与MOD和LO相比，HI中MVIC期间力发展速率和峰值扭矩（PT）的下降百分比以及肌肉疲劳方案期间PT和平均扭矩的变化均较低。此外，绝对和相对膳食蛋白质摄入量更大，HI相比，MOD或LO。结果表明，更大的肌内肌肽含量反映了更大的膳食蛋白质摄入量，并且具有更高肌肽含量的个体与具有较低肌肽的个体相比显示出更大的疲劳衰减。
Carnosine is a naturally occurring intramuscular dipeptide that is thought to attenuate fatigue during high-intensity exercise. Carnosine content is influenced by various factors, including gender and diet. Despite research reporting that carnosine content is lower in women compared to men and lower in vegetarians compared to omnivores, no investigations have examined carnosine content in women based on dietary protein intake and its effect on muscle fatigue. Twenty recreationally active women were assigned to either a high (HI; n = 5), moderate (MOD; n = 10), or low (LO; n = 5) group based upon intramuscular carnosine content of the vastus lateralis. Each participant underwent two unilateral maximal voluntary isometric contractions (MVIC) of the knee extensors separated by an isokinetic exercise protocol consisting of five sets of 50 repeated maximal unilateral contractions. Magnitude-based inferences were used to analyze group differences. Percent decline in rate of force development and peak torque (PT) during the MVICs and changes in PT and mean torque during the muscle-fatiguing protocol were lower in HI compared to both MOD and LO. Additionally, absolute and relative dietary protein intake were greater in HI compared to MOD or LO. Results indicated that greater intramuscular carnosine content was reflective of greater dietary protein intake and that individuals with higher carnosine content displayed a greater attenuation of fatigue compared to those with lower carnosine.
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