Tumor-Derived Extracellular Vesicles and the Immune System-Lessons From Immune-Competent Mouse-Tumor Models.
Tumor-Derived Extracellular Vesicles and the Immune System-Lessons From Immune-Competent Mouse-Tumor Models.
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DOI：
10.3389/fimmu.2020.606859
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发表时间：
2020
影响因子：
7.3
通讯作者：
Eliceiri BP
中科院分区：
文献类型：
--
作者：
Droste M;Thakur BK;Eliceiri BP
肿瘤来源的细胞外囊泡（TEV）是癌症免疫反应的重要调节剂;然而，迄今为止，大多数研究都是使用细胞培养系统进行的。免疫活性鼠肿瘤模型目前提供了使用体内动物模型评估TEV的拟议作用的最佳平台，因此对于检查TEV与免疫系统之间的相互作用很重要。在这篇综述中，我们提出了目前的知识TEVs使用体内荷瘤动物模型，重点是TEVs在介导肿瘤细胞和适应性和先天免疫细胞之间的串扰的作用。特别是，我们解决的问题，动物模型如何能够澄清的异质性TEV的影响，在抗肿瘤反应和逃避免疫监视。TEV在介导直接抗原呈递功能方面的潜力支持其作为癌症疫苗治疗剂的潜力，因此，我们概述了具有新型免疫疗法潜力的TEV试验的关键发现，并阐明了首次人体试验的挑战。我们还强调了继续提高EV研究的严谨性和可重复性的方法的重要更新，特别是在功能性动物模型中。
Tumor-derived extracellular vesicles (TEVs) are important regulators of the immune response in cancer; however, most research so far has been carried out using cell culture systems. Immune-competent murine tumor models currently provide the best platform to assess proposed roles of TEVs using in vivo animal models and therefore are important for examining interactions between TEVs and the immune system. In this review, we present the current knowledge on TEVs using in vivo tumor-bearing animal models, with a focus on the role of TEVs in mediating crosstalk between tumor cells and both adaptive and innate immune cells. In particular, we address the question how animal models can clarify the reported heterogeneity of TEV effects in both anti-tumor responses and evasion of immune surveillance. The potential of TEVs in mediating direct antigen-presenting functions supports their potential as cancer vaccine therapeutics, therefore, we provide an overview of key findings of TEV trials that have the potential as novel immunotherapies, and shed light on challenges in the path toward the first in-human trials. We also highlight the important updates on the methods that continue to enhance the rigor and reproducibility of EV studies, particularly in functional animal models.
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影响因子：
7.3
作者：
Andreu Z;Yáñez-Mó M
通讯作者：
Yáñez-Mó M
影响因子：
7.3
作者：
Barros FM;Carneiro F;Machado JC;Melo SA
通讯作者：
Melo SA
影响因子：
11.2
作者：
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通讯作者：
Thery, Clotilde
影响因子：
50.3
作者：
Becker A;Thakur BK;Weiss JM;Kim HS;Peinado H;Lyden D
通讯作者：
Lyden D
影响因子：
3.8
作者：
Bardi GT;Smith MA;Hood JL
通讯作者：
Hood JL