Cerebellar transcranial alternating current stimulation in the gamma range applied during the acquisition of a novel motor skill
Cerebellar transcranial alternating current stimulation in the gamma range applied during the acquisition of a novel motor skill
复制标题
在获得新的运动技能过程中应用伽玛范围内的小脑经颅交流电刺激
作者：
M. Wessel;L. Draaisma;Anne F. W. de Boer;Chang;P. Maceira;M. Durand;P. Koch;T. Morishita;F. Hummel
发展新的策略来增加运动训练的成功是非常感兴趣的健康人和神经系统患者。训练与经颅电刺激相结合是一种很有前景的方法。然而，有限的可重复性和不同的效应大小使得进一步的方案优化是必要的。我们测试了一种新的小脑经颅交流电刺激方案（tACS）对运动技能学习的影响。此外，我们通过经颅磁刺激和基于fmri的静息状态连接分析来研究潜在的机制。N = 15名年轻、健康的参与者被招募。在双盲、假对照、交叉设计中，将50 Hz的tACS应用于左小脑，同时获得一种新的运动技能。通过在假设驱动的运动学习网络中研究休息时的短时间皮质内抑制（siicirest）和运动前阶段（siicimove）、休息时的皮质内促进（ICFrest）和基于种子的静息状态fmri的功能连接（FC），评估了潜在的潜在机制。主动刺激并不能提高技能的习得或保留。对纹状体-顶叶FC有轻微影响。线性混合效应模型确定sicmove调制和基线任务表现是预测训练成功的最具影响力的决定因素。考虑到已确定的因素，可以对参与者进行分层，以便将来进行基于培训的干预。
The development of novel strategies to augment motor training success is of great interest for healthy persons and neurological patients. A promising approach is the combination of training with transcranial electric stimulation. However, limited reproducibility and varying effect sizes make further protocol optimization necessary. We tested the effects of a novel cerebellar transcranial alternating current stimulation protocol (tACS) on motor skill learning. Furthermore, we studied underlying mechanisms by means of transcranial magnetic stimulation and analysis of fMRI-based resting-state connectivity. N = 15 young, healthy participants were recruited. 50 Hz tACS was applied to the left cerebellum in a double-blind, sham-controlled, cross-over design concurrently to the acquisition of a novel motor skill. Potential underlying mechanisms were assessed by studying short intracortical inhibition at rest (SICIrest) and in the premovement phase (SICImove), intracortical facilitation at rest (ICFrest), and seed-based resting-state fMRI-based functional connectivity (FC) in a hypothesis-driven motor learning network. Active stimulation did not enhance skill acquisition or retention. Minor effects on striato-parietal FC were present. Linear mixed effects modelling identified SICImove modulation and baseline task performance as the most influential determining factors for predicting training success. Accounting for the identified factors may allow to stratify participants for future training-based interventions.
影响因子：
2.5
作者：
H. V. Mier;L. W. Tempel;J. Perlmutter;M. Raichle;S. Petersen
通讯作者：
H. V. Mier;L. W. Tempel;J. Perlmutter;M. Raichle;S. Petersen
影响因子：
5.3
作者：
Cantarero, Gabriela;Spampinato, Danny;Celnik, Pablo
通讯作者：
Celnik, Pablo