Association of physical activity intensity and bout length with mortality: An observational study of 79,503 UK Biobank participants.
Association of physical activity intensity and bout length with mortality: An observational study of 79,503 UK Biobank participants.
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DOI：
10.1371/journal.pmed.1003757
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发表时间：
2021-09
期刊：
影响因子：
15.8
通讯作者：
Lawlor DA
中科院分区：
文献类型：
--
作者：
Millard LAC;Tilling K;Gaunt TR;Carslake D;Lawlor DA
花更多的时间运动(减少久坐)与健康益处相关，如改善心血管健康和降低全因死亡的风险。目前尚不清楚这些联系是否有所不同，这取决于久坐不动或中等强度体力活动(MVPA)的时间是在长时间还是短时间内积累的。在这项研究中，我们使用了一种考虑替代的新方法(即在MVPA中更多的时间意味着更少的睡眠时间，在轻度活动或久坐中)来检查久坐和MVPA发作的时间是否与全因死亡率有关。我们使用了79,503名成年参与者的数据，这些数据来自以人口为基础的英国生物库队列，该队列在2006至2010年间招募了参与者(加速计的平均年龄为62.1岁[SD=7.9]，54.5%的女性；平均随访时间为5.1年[SD=0.73])。我们得出了(1)参与者平均每天花在活动类别-睡眠、久坐、轻微活动和MVPA上的总时间；(2)花在短(1-15分钟)、中等(16-40分钟)和长(41+分钟)持续时间的久坐时间；(3)非常短(1-9分钟)、短(10-15分钟)、中等(16-40分钟)和长(41+分钟)的MVPA持续时间。我们使用COX比例风险回归来估计在一种活动或比赛长度类别中平均每天多花10分钟时间，而在另一种活动或比赛长度类别中少花10分钟时间与全因死亡率的关系。那些花更多时间在MVPA上的人死亡风险较低，无论这些替代时间是用于睡眠、久坐还是轻度活动，这些关联具有相似的幅度(例如，每增加10分钟MVPA，加上每天减少10分钟轻度活动，危险比[HR]0.96[95%CI：0.94P<；0.001])。如果用这种方法取代轻度活动(每10分钟多坐10分钟，每天减少10分钟轻度活动)，那些久坐时间较长的人死亡风险更高(HR1.02[95%CI：1.01，1.02；P<；0.001])；如果用这种方法取代MVPA(每多坐10分钟，每天减少10分钟，P<；0.001)，死亡风险更高。我们发现几乎没有证据表明死亡风险取决于久坐或MVPA发作的时间长短。我们研究的主要局限性是潜在的残留混杂、有限的随访时间以及对英国人口的精选样本的使用。我们已经证明，花在MVPA上的时间与较低的死亡率相关，无论它是否取代了睡眠、久坐或轻度活动的时间。久坐的时间与更高的死亡风险相关，特别是如果它取代了MVPA。这凸显了MVPA的特殊重要性。我们的发现表明，MVPA的影响并不取决于它是从几场短比赛中获得还是从较少的较长比赛中获得，这支持了最近取消了英国和美国的政策中关于MVPA应在10分钟或更长时间内累积的要求。需要进一步的研究来调查因果关系，并探索死亡率以外的健康后果。路易丝·米勒德和他的同事研究了几次中等到剧烈的体力活动与死亡率之间的关系。花更多的时间活动，减少久坐的时间与许多健康益处相关。目前尚不清楚这些益处是否有所不同，是活动时间或久坐时间是在较长时间与较短时间内累积的，还是取决于它们所取代的活动类型。英国和美国最近的政策变化取消了运动应该累积在10分钟以上的建议。我们使用了79,503名英国成年参与者的数据，并评估了如果人们进行较长时间的中等强度体力活动(MVPA)或久坐行为，死亡风险是否会有所不同。我们发现，无论是取代光活动、久坐时间还是睡眠，花在MVPA上的时间越长，死亡风险都越低；久坐时间越长，死亡风险越高，特别是如果它取代了MVPA。我们发现几乎没有证据表明死亡风险取决于MVPA或久坐不动的时间长短。增加花在MVPA上的时间或减少久坐时间(或两者兼而有之)的干预措施可能有益于健康。花在MVPA上的任何时间都可能是有益的，即使是较短(例如，1分钟)的比赛，支持英国和美国最近的政策变化，取消了MVPA应累积在10分钟或更长时间的要求。
Spending more time active (and less sedentary) is associated with health benefits such as improved cardiovascular health and lower risk of all-cause mortality. It is unclear whether these associations differ depending on whether time spent sedentary or in moderate-vigorous physical activity (MVPA) is accumulated in long or short bouts. In this study, we used a novel method that accounts for substitution (i.e., more time in MVPA means less time sleeping, in light activity or sedentary) to examine whether length of sedentary and MVPA bouts associates with all-cause mortality. We used data on 79,503 adult participants from the population-based UK Biobank cohort, which recruited participants between 2006 and 2010 (mean age at accelerometer wear 62.1 years [SD = 7.9], 54.5% women; mean length of follow-up 5.1 years [SD = 0.73]). We derived (1) the total time participants spent in activity categories—sleep, sedentary, light activity, and MVPA—on average per day; (2) time spent in sedentary bouts of short (1 to 15 minutes), medium (16 to 40 minutes), and long (41+ minutes) duration; and (3) MVPA bouts of very short (1 to 9 minutes), short (10 to 15 minutes), medium (16 to 40 minutes), and long (41+ minutes) duration. We used Cox proportion hazards regression to estimate the association of spending 10 minutes more average daily time in one activity or bout length category, coupled with 10 minutes less time in another, with all-cause mortality. Those spending more time in MVPA had lower mortality risk, irrespective of whether this replaced time spent sleeping, sedentary, or in light activity, and these associations were of similar magnitude (e.g., hazard ratio [HR] 0.96 [95% CI: 0.94, 0.97; P < 0.001] per 10 minutes more MVPA, coupled with 10 minutes less light activity per day). Those spending more time sedentary had higher mortality risk if this replaced light activity (HR 1.02 [95% CI: 1.01, 1.02; P < 0.001] per 10 minutes more sedentary time, with 10 minutes less light activity per day) and an even higher risk if this replaced MVPA (HR 1.06 [95% CI: 1.05, 1.08; P < 0.001] per 10 minutes more sedentary time, with 10 minutes less MVPA per day). We found little evidence that mortality risk differed depending on the length of sedentary or MVPA bouts. Key limitations of our study are potential residual confounding, the limited length of follow-up, and use of a select sample of the United Kingdom population. We have shown that time spent in MVPA was associated with lower mortality, irrespective of whether it replaced time spent sleeping, sedentary, or in light activity. Time spent sedentary was associated with higher mortality risk, particularly if it replaced MVPA. This emphasises the specific importance of MVPA. Our findings suggest that the impact of MVPA does not differ depending on whether it is obtained from several short bouts or fewer longer bouts, supporting the recent removal of the requirement that MVPA should be accumulated in bouts of 10 minutes or more from the UK and the United States policy. Further studies are needed to investigate causality and explore health outcomes beyond mortality. Louise Millard and co-workers study associations between bouts of moderate-to-vigorous physical activity and mortality. Spending more time active and less time sedentary is associated with many health benefits. It is currently not clear whether these benefits differ if time spent active or sedentary is accumulated in longer versus shorter bouts or depending on which type of activity they replace. Recent policy changes in the UK and the US removed the recommendation that activity should be accumulated in bouts of 10 minutes of more. We used data on 79,503 UK-based adult participants and assessed whether mortality risk differed if people did longer versus shorter bouts of moderate-vigorous physical activity (MVPA) or sedentary behaviour. We found that more time spent in MVPA was associated with lower mortality risk irrespective of whether it replaced light activity, sedentary time, or sleep; more time spent sedentary was associated with higher mortality risk, particularly if it replaced MVPA. We found little evidence to suggest that mortality risk differs depending on the length of MVPA or sedentary bouts. Interventions that increase time spent in MVPA or reduce sedentary time (or both) could benefit health. Any time spent in MVPA may be beneficial, even bouts of shorter (e.g., 1 minute) duration, supporting recent UK and US policy changes removing the requirement that MVPA should be accumulated in bouts of 10 minutes or more.
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DOI：
10.3945/ajcn.115.110924
发表时间：
2015-08
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Bell JA;Hamer M;van Hees VT;Singh-Manoux A;Kivimäki M;Sabia S
通讯作者：
Sabia S
DOI：
10.1186/1479-5868-11-34
发表时间：
2014-03-10
期刊：
The international journal of behavioral nutrition and physical activity
影响因子：
--
作者：
Orme M;Wijndaele K;Sharp SJ;Westgate K;Ekelund U;Brage S
通讯作者：
Brage S
影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
影响因子：
7.7
作者：
Millard, Louise A. C.;Tilling, Kate;Gaunt, Tom R.
通讯作者：
Gaunt, Tom R.
影响因子：
120.7
作者：
Piercy, Katrina L.;Troiano, Richard P.;Ballard, Rachel M.;Carlson, Susan A.;Fulton, Janet E.;Galuska, Deborah A.;George, Stephanie M.;Olson, Richard D.
通讯作者：
Olson, Richard D.