Proton nuclear Overhauser effect study of the structure of a deoxyoligonucleotide duplex in aqueous solution.
Proton nuclear Overhauser effect study of the structure of a deoxyoligonucleotide duplex in aqueous solution.
复制标题
水溶液中脱氧寡核苷酸双链体结构的质子核奥弗豪瑟效应研究。
作者：
D. Reid;S. Salisbury;S. Bellard;Z. Shakked;D. Williams
Nuclear Overhauser enhancements (NOEs) have been observed between some of the nonexchangeable protons of the self-complementary octanucleoside heptaphosphate d(G-G-T-A-T-A-C-C) in conditions under which duplex formation takes place. Comparison of inter- and intraresidue NOEs has made possible the assignment of all the aromatic and 1'- and 2'-ribosyl signals. In particular, and with the exception of the 5' terminal, NOEs of comparable magnitude are observed between H-8 of purines or H-6 of pyrimidines and pairs of anomeric protons. There are the H-1's of the nucleotide containing the relevant aromatic proton and those of the adjacent residue in the 5' direction. Differentially evolving NOEs are also generated between aromatic protons and the C-2' methylene protons on both the same residue and on the neighboring 5' residue. The relative magnitudes of these NOEs are discussed in terms of overall helical geometry and are consistent with a generally accepted B-type DNA model (R. Chandrasekaran and S. Arnott, personal communications).
利用核奥弗豪瑟效应研究核糖核酸中核糖核酸的环境。
影响因子：
2.9
作者：
Tropp,J;Redfield,AG
通讯作者：
Redfield,AG
12 碱基对限制性片段的 300 MHz 和 600 MHz 质子 NMR 研究：通过弛豫测量研究结构。
影响因子：
14.9
作者：
Early,TA;Kearns,DR;Hillen,W;Wells,RD
通讯作者：
Wells,RD