Targeting pericytes for angiogenic therapies.
Targeting pericytes for angiogenic therapies.
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DOI：
10.1111/micc.12107
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Murfee WL
中科院分区：
文献类型：
--
作者：
Kelly-Goss MR;Sweat RS;Stapor PC;Peirce SM;Murfee WL
在病理情况下，如肿瘤生长和糖尿病视网膜病变，阻断血管生成将是有益的。在其他情况下，如心肌梗死和高血压，促进血管生成可能是可取的。由于其对内皮细胞的推定影响，血管周细胞已成为越来越感兴趣的话题，并越来越多地被评估为血管调节疗法的潜在靶点。例如，操纵周细胞向毛细血管募集的策略可能导致抗或促血管生成作用。然而，我们目前的理解是有限的知识差距周细胞的身份和血统。使用音乐类比，这篇评论是一个“混搭”，试图整合我们所知道的周细胞的功能和表达与什么是开始阐明其再生潜力。我们探讨挥之不去的问题，周细胞表型的身份和血统。不同周细胞标记物（例如，SMA、结蛋白、NG 2和PDGFR-β）对于不同的亚群和组织是不同的。以前使用这些标记物来鉴定周细胞已经表明了潜在的表型重叠和对其他细胞表型的可塑性。我们的综述记录了文献的状态，确定了关键的未回答的问题，并激发了未来的研究，旨在了解这种有趣的细胞类型并利用其治疗潜力。
In pathological scenarios, such as tumor growth and diabetic retinopathy, blocking angiogenesis would be beneficial. In others, such as myocardial infarction and hypertension, promoting angiogenesis might be desirable. Due to their putative influence on endothelial cells, vascular pericytes have become a topic of growing interest and are increasingly being evaluated as a potential target for angioregulatory therapies. For example, the strategy of manipulating pericyte recruitment to capillaries could result in anti- or pro-angiogenic effects. However, our current understanding of pericytes is limited by knowledge gaps regarding pericyte identity and lineage. To use a music analogy, this review is a “mash-up” that attempts to integrate what we know about pericyte functionality and expression with what is beginning to be elucidated regarding their regenerative potential. We explore the lingering questions regarding pericyte phenotypic identity and lineage. The expression of different pericyte markers (e.g., SMA, Desmin, NG2 and PDGFR-β) varies for different subpopulations and tissues. Previous use of these markers to identify pericytes has suggested potential phenotypic overlaps and plasticity toward other cell phenotypes. Our review chronicles the state of the literature, identifies critical unanswered questions, and motivates future research aimed at understanding this intriguing cell type and harnessing its therapeutic potential.
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4.4
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