Elevated alcohol consumption following alcohol cue exposure is partially mediated by reduced inhibitory control and increased craving.
Elevated alcohol consumption following alcohol cue exposure is partially mediated by reduced inhibitory control and increased craving.
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DOI：
10.1007/s00213-017-4694-6
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发表时间：
2017-10
影响因子：
3.4
通讯作者：
Jones A
中科院分区：
文献类型：
--
作者：
Field M;Jones A
暴露于酒精相关的线索导致酒精消费增加，这可能部分归因于暂时受损的冲动控制。我们调查，如果暴露于酒精线索会损害抑制控制，如果这种损害的程度将部分介导的酒精线索对随后的自愿饮酒的影响。我们招募了81名重度饮酒者（50名女性），他们在随机分配到酒精线索暴露组或对照组之前完成了抑制控制（停止信号任务）和主观渴望的基线测量。酒精线索曝光组，然后完成了第二个停止信号的任务（嵌入酒精线索），同时暴露于嗅觉酒精线索，在酒精的背景下。控制组完成了第二个停止信号任务（嵌入水线索），伴随着暴露于水线索，在一个中性的背景下。然后，测量所有参与者的主观渴望和随意饮酒量。与对照组相比，酒精提示暴露组的抑制控制恶化（与基线相比）程度更大。与对照组相比，酒精提示暴露组的渴望和随意饮酒量增加，尽管酒精摄入量的组间差异没有统计学意义。为了支持我们的假设，多个中介分析表明，酒精线索暴露后随意饮酒量的增加部分是由抑制控制受损和渴望增加介导的。这些研究结果表明，抑制控制的状态波动是一个潜在的机制，通过酒精线索增加饮酒行为。本文的在线版本（doi：10.1007/s 00213 -017-4694-6）包含补充材料，可供授权用户使用。
Exposure to alcohol-related cues leads to increased alcohol consumption, and this may be partially attributable to momentarily impaired impulse control. We investigated if exposure to alcohol cues would impair inhibitory control and if the extent of this impairment would partially mediate the effect of alcohol cues on subsequent voluntary alcohol consumption. We recruited 81 heavy drinkers (50 female) who completed baseline measures of inhibitory control (stop-signal task) and subjective craving before random allocation to an alcohol cue exposure or control group. The alcohol cue exposure group then completed a second stop-signal task (with embedded alcohol cues) with concurrent exposure to olfactory alcohol cues, in an alcohol context. The control group completed a second stop-signal task (with embedded water cues), accompanied by exposure to water cues, in a neutral context. Then, subjective craving and ad libitum alcohol consumption were measured in all participants. Inhibitory control worsened (compared to baseline) to a greater extent in the alcohol cue exposure group compared to the control group. Craving and ad libitum alcohol consumption were elevated in the alcohol cue exposure group compared to the control group, although the group difference in alcohol consumption fell short of statistical significance. In support of our hypotheses, multiple mediation analyses demonstrated that elevated ad libitum alcohol consumption following alcohol cue exposure was partially mediated by both impaired inhibitory control and increased craving. These findings suggest that state fluctuations in inhibitory control are a potential mechanism through which alcohol cues increase drinking behaviour. The online version of this article (doi:10.1007/s00213-017-4694-6) contains supplementary material, which is available to authorized users.
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影响因子：
2.3
作者：
Jones, Andrew;Field, Matt
通讯作者：
Field, Matt
影响因子：
3.4
作者：
Bickel, Warren K.;Jarmolowicz, David P.;Mueller, E. Terry;Gatchalian, Kirstin M.;McClure, Samuel M.
通讯作者：
McClure, Samuel M.
影响因子：
19.9
作者：
Guitart-Masip, Marc;Duzel, Emrah;Dolan, Ray;Dayan, Peter
通讯作者：
Dayan, Peter
DOI：
10.1111/add.12283
发表时间：
2013-11
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Fernie G;Peeters M;Gullo MJ;Christiansen P;Cole JC;Sumnall H;Field M
通讯作者：
Field M
DOI：
10.1111/j.1530-0277.2010.01243.x
发表时间：
2010-09-01
影响因子：
3.2
作者：
Gauggel, Siegfried;Heusinger, Anne;Staedtgen, Mario
通讯作者：
Staedtgen, Mario