Normative Left Ventricular M-Mode Echocardiographic Values in Preterm Infants up to 2 kg.

Normative Left Ventricular M-Mode Echocardiographic Values in Preterm Infants up to 2 kg.
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DOI:
10.1016/j.echo.2017.04.010
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发表时间:
2017-08
期刊:
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
影响因子:
--
通讯作者:
Johnson MC
Johnson MC
中科院分区:
其他
文献类型:
--
作者:
Choudhry S;Salter A;Cunningham TW;Levy PT;Nguyen HH;Wallendorf M;Singh GK;Johnson MC

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早产儿的超声心动图数据缺乏规范性。本研究的目的是:(1)得出左室(LV) m模式参考值,(2)比较早产儿左室尺寸和质量(LVM)索引替代方法的性能。我们建议索引LV测量早产儿体重是一种实用的方法,考虑到婴儿卷尺长度测量的可变性。在这项回顾性研究中,对503名≤2 Kg的住院早产儿(回顾性样本372例,前瞻性纳入131例)重新测量舒张末期室间隔厚度(IVSd)、舒张末期左室后壁厚度(LVPWd)、左室舒张末期和收缩末期尺寸(LVEDD、LVESD)、LVM和相对壁厚度(RWT)。所有变量的测量在回顾性和前瞻性样本之间没有差异,因此结果是汇总的。使用Cole 's lambda-mu-sigma方法生成体重、长度和体表面积(BSA)性别特异性百分位曲线的LV维度和LVM索引以及相应的Z分数。阈值限制(第10和第80百分位;P10, P80)用于生成RWT规范范围。以体重为指标的LVM、IVSd、LVPWd、LVEDD和LVESD的性别分位数曲线与使用长度和BSA生成的曲线相似。RWT的平均[P10, P80]正常范围为0.33(0.26,0.38)。从这个庞大的早产儿队列中,我们开发了LV m模式维度和LVM百分位曲线,以体重为指标,作为评估早产儿LV形态的实用方法。
There is a paucity of normative echocardiographic data in preterm infants. The objectives of this study were: (1) derive left ventricular (LV) M-mode reference values, and (2) compare the performance of alternative methods of indexing LV dimensions and mass (LVM) in preterm infants. We propose that indexing LV measures to weight in preterm infants is a practical approach given the variability associated with tape-measure length measurement in infants. In this retrospective study LV M-mode echocardiographic measurements of end diastolic interventricular septal thickness (IVSd), end diastolic LV posterior wall thickness (LVPWd), LV end diastolic and systolic dimensions (LVEDD, LVESD), LVM, and relative wall thickness (RWT) were remeasured in 503 hospitalized preterm infants ≤ 2 Kg (372 from a retrospective sample and 131 prospectively enrolled). Measures for all variables did not differ between retrospective and prospective samples so results were pooled. LV dimensions and LVM indexed for weight, length, and body surface area (BSA) sex-specific centile curves and corresponding Z scores were generated using Cole’s lambda-mu-sigma method. Threshold limits (10th, and 80th percentile; P10, P80) were used to generate RWT normative range. Sex-specific centile curves using LVM, IVSd, LVPWd, LVEDD, and LVESD indexed to weight were similar to the curves generated using length and BSA. The mean [P10, P80] normal range for RWT was 0.33 (0.26, 0.38). From this large cohort of preterm infants, we developed LV M-mode dimension and LVM centile curves indexed to weight as a practical method to assess LV morphology in preterm infants.
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