ECM-modulated cellular dynamics as a driving force for tissue morphogenesis.
ECM-modulated cellular dynamics as a driving force for tissue morphogenesis.
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DOI：
10.1016/j.gde.2013.05.005
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发表时间：
2013-08
影响因子：
4
通讯作者：
Yamada, Kenneth M.
中科院分区：
文献类型：
--
作者：
Daley, William P.;Yamada, Kenneth M.
细胞外基质（ECM）在整个发育过程中发挥着多种调节作用。组织内细胞与ECM之间的协调相互作用导致ECM结构的动态重塑。这种微环境重塑所产生的化学信号和物理力量调节着塑造组织结构的细胞行为。在这里，我们回顾了最近的发现，说明在组织形态发生过程中，ECM重塑促进动态细胞行为的不同方式。我们首先聚焦于确定局部ECM信号作为分支形态发生过程中细胞迁移、形状和粘附的调节因子的新见解。我们还回顾了ECM和基底膜塑造和稳定上皮组织结构的机制，以果蝇卵室发育和上皮器官裂的形成为例。最后，我们概述了ECM调节干细胞分化以促进适当组织形态发生的动态机制。
The extracellular matrix (ECM) plays diverse regulatory roles throughout development. Coordinate interactions between cells within a tissue and the ECM result in the dynamic remodeling of ECM structure. Both chemical signals and physical forces that result from such microenvironmental remodeling regulate cell behavior that sculpts tissue structure. Here, we review recent discoveries illustrating different ways in which ECM remodeling promotes dynamic cell behavior during tissue morphogenesis. We focus first on new insights that identify localized ECM signaling as a regulator of cell migration, shape, and adhesion during branching morphogenesis. We also review mechanisms by which the ECM and basement membrane can both sculpt and stabilize epithelial tissue structure, using as examples Drosophila egg chamber development and cleft formation in epithelial organs. Finally, we end with an overview of the dynamic mechanisms by which the ECM can regulate stem cell differentiation to contribute to proper tissue morphogenesis.
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影响因子：
2.7
作者：
Daley, William P.;Gulfo, Kathryn M.;Sequeira, Sharon J.;Larsen, Melinda
通讯作者：
Larsen, Melinda
影响因子：
64.5
作者：
Fujiwara H;Ferreira M;Donati G;Marciano DK;Linton JM;Sato Y;Hartner A;Sekiguchi K;Reichardt LF;Watt FM
通讯作者：
Watt FM
DOI：
10.1126/science.1199424
发表时间：
2011-02-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Haigo SL;Bilder D
通讯作者：
Bilder D
影响因子：
2.5
作者：
Daley, William P.;Kohn, Joshua M.;Larsen, Melinda
通讯作者：
Larsen, Melinda
影响因子：
82.9
作者：
Bi, Yanming;Ehirchiou, Driss;Young, Marian F.
通讯作者：
Young, Marian F.