Altered myelin maturation in four year old children born very preterm
Altered myelin maturation in four year old children born very preterm
复制标题
四岁早产儿的髓磷脂成熟发生改变
DOI：
10.1016/j.nicl.2018.101635
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
J. Sled
中科院分区：
文献类型：
--
作者：
M. Vandewouw;J. M. Young;M. Shroff;Margot J. Taylor;J. Sled
极早产儿（VPT；胎龄<32周[GA]）出现一系列认知缺陷的风险更大，这些缺陷通常在学龄期表现出来。在这里，我们检验了这样的假设：这些儿童的髓磷脂成熟度发生了改变，这可以在学龄前通过髓磷脂敏感的 MRI 测量来检测到。我们纳入了 33 名出生 VPT 的四岁儿童（平均 GA；28.7 周）和 23 名四岁足月 (FT) 儿童，并完成了磁化转移 (MT)、T1 加权 (T1-w) 和 T2 加权 (T1-w) 磁共振成像以及发育评估。计算 MT 比率 (MTR) 和 T1-w/T2-w 比率图像，并使用白质中基于束的空间统计 (TBSS) 以及白质、皮质下灰质和皮质灰质中的感兴趣区域 (ROI) 分析来探讨组间差异。在所有三个脑区中研究了 MTR 和 T1-w/T2-w 比率之间的关系以及与发育评估的关系。在出生的 VPT 儿童中，TBSS 和 ROI 分析显示，与出生的 FT 儿童相比，白质的 MTR 和 T1-w/T2-w 比值均显着降低。 ROI 分析显示，与 FT 儿童相比，VPT 儿童的丘脑、壳核和杏仁核以及枕叶和颞叶的 T1-w/T2-w 比值有所降低。在 VPT 和 FT 儿童中，T1-w/T2-w 比值和 MTR 在白质、皮质下灰质和皮质灰质中高度相关。这两项指标均与个体白质束以及皮质和皮质下 ROI 的发育评估呈正相关，表明较高的 MTR 和 T1-w/T2-w 比率与更好的认知表现相关。这些发现与 VPT 出生儿童髓鞘形成延迟一致。
Children born very preterm (VPT; <32 weeks gestational age [GA]) are at greater risk for a range of cognitive deficits that typically manifest at school age. Here we examine the hypothesis that these children have altered myelin maturational that can be detected by myelin sensitive MRI measures prior to school age. We included 33 four-year old children born VPT (mean GA; 28.7 weeks) and 23 four-year old full term (FT) children and completed magnetization transfer (MT), T1-weighted (T1-w) and T2-weighted (T1-w) magnetic resonance imaging as well as developmental assessments. Both MT ratio (MTR) and T1-w/T2-w ratio images were calculated, and group differences were probed using tract-based spatial statistics (TBSS) in white matter, and region of interest (ROI) analysis in white, subcortical gray and cortical gray matter. The relations between MTR and T1-w/T2-w ratio, as well as with developmental assessments, were investigated in all three brain divisions. In children born VPT, TBSS and ROI analysis revealed that both MTR and T1-w/T2-w ratio were significantly reduced in white matter compared to children born FT. ROI analysis showed reductions in T1-w/T2-w ratio in VPT children compared to FT children in the thalamus, putamen and amygdala, as well as in the occipital and temporal lobes. Across the VPT and FT children, T1-w/T2-w ratio and MTR were highly correlated across white, subcortical gray and cortical gray matter. Both measures correlated positively with developmental assessments in individual white matter tracts and cortical and subcortical ROIs, suggesting that higher MTR and T1-w/T2-w ratio is related to better cognitive performance. Together these findings are consistent with delayed myelination in VPT born children.
登录
查看更多内容
DOI：
--
发表时间：
2002-09
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Y. Ge;R. Grossman;J. Babb;Marcie L. Rabin;L. J. Mannon;D. Kolson
通讯作者：
Y. Ge;R. Grossman;J. Babb;Marcie L. Rabin;L. J. Mannon;D. Kolson
影响因子：
11.2
作者：
Righart R;Biberacher V;Jonkman LE;Klaver R;Schmidt P;Buck D;Berthele A;Kirschke JS;Zimmer C;Hemmer B;Geurts JJG;Mühlau M
通讯作者：
Mühlau M
人类深部大脑 MRI 图谱。
影响因子：
3.4
作者：
Lemaire,Jean-Jacques;DeSalles,Antonio;Coll,Guillaume;ElOuadih,Youssef;Chaix,Rémi;Coste,Jérôme;Durif,Franck;Makris,Nikos;Kikinis,Ron
通讯作者：
Kikinis,Ron
DOI：
10.1093/cercor/bhr176
发表时间：
2012-05
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Ball G;Boardman JP;Rueckert D;Aljabar P;Arichi T;Merchant N;Gousias IS;Edwards AD;Counsell SJ
通讯作者：
Counsell SJ