Cellular mechanobiology of the intervertebral disc: new directions and approaches.
Cellular mechanobiology of the intervertebral disc: new directions and approaches.
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DOI：
10.1016/j.jbiomech.2009.09.019
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发表时间：
2010-01-05
影响因子：
2.4
通讯作者：
Twomey JD
中科院分区：
文献类型：
--
作者：
Hsieh AH;Twomey JD
我们对椎间盘（IVD）了解得越多，我们就越能理解力通过ECM传递到细胞的复杂性，以及它对机械应力反应的生物决定因素。这篇综述强调了我们对IVD生理学知识的最新进展，并探讨了它们对细胞机械生物学的影响。讨论围绕髓核（NP）和纤维环（AF）的细胞和显微结构解剖学的不断发展，以响应支持轴向负荷和脊柱运动产生的复杂应力。特别关注来自未成熟NP和层间AF的细胞，并评估其对IVD健康和功能的潜在机械生物学贡献。此外，几个创新的方法，已被带到承担研究椎间盘细胞和它们的微机械环境之间的相互作用进行了讨论。“工程”细胞功能的技术和制造结构更明确的生物材料支架的技术最近已被用于椎间盘研究。这些工具可用于阐明机械应力调节不同IVD细胞群的生物学和物理机制，并有助于预防和治疗措施的进步。
The more we learn about the intervertebral disc (IVD), the more we come to appreciate the intricacies involved in transmission of forces through the ECM to the cell, and in the biological determinants of its response to mechanical stress. This review highlights recent developments in our knowledge of IVD physiology and examines their impact on cellular mechanobiology. Discussion centers around the continually evolving cellular and microstructural anatomy of the nucleus pulposus (NP) and the annulus fibrosus (AF) in response to complex stresses generated in support of axial load and spinal motion. Particular attention has been given to cells from the immature NP and the interlamellar AF, and assessment of their potential mechanobiologic contributions to the health and function of the IVD. In addition, several innovative approaches that have been brought to bear on studying the interplay between disc cells and their micromechanical environment are discussed. Techniques for “engineering” cellular function and technologies for fabricating more structurally defined biomaterial scaffolds have recently been employed in disc research. Such tools can be used to elucidate the biological and physical mechanisms by which different IVD cell populations are regulated by mechanical stress, and contribute to advancement of preventative and therapeutic measures.
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影响因子：
6.9
作者：
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通讯作者：
Setton, LA
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作者：
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通讯作者：
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作者：
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