Structure-function relationships in peptoids: recent advances toward deciphering the structural requirements for biological function.
Structure-function relationships in peptoids: recent advances toward deciphering the structural requirements for biological function.
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DOI：
10.1039/b817980h
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发表时间：
2009-04-21
影响因子：
3.2
通讯作者：
Blackwell HE
中科院分区：
文献类型：
--
作者：
Fowler SA;Blackwell HE
N-取代甘氨酸的低聚物或类肽是探测生物过程的通用工具，并有望作为治疗剂。在大多数最近的类肽研究中的一个潜在主题是类肽功能和类肽结构之间的联系。对于某些应用，良好折叠的类肽对于活性是必不可少的，而对于其他应用，非结构化的类肽似乎足够，甚至是上级的。目前，这些结构-功能连接主要是在设计、合成和表征过程之后进行的。然而，随着类肽折叠指南的阐明和已知的生物活性的扩展，我们预计这些连接将提供一条通往功能性类肽从头设计的途径。在这个角度来看，我们回顾了几个类肽的结构与功能的关系，已划定在过去的五年。类肽已成为一类有价值的折叠体，用于研究生物分子相互作用，并有望作为治疗剂。这一观点分析了过去五年中类肽结构在发现生物活性类肽中的重要性。
Oligomers of N-substituted glycine, or peptoids, are versatile tools to probe biological processes and hold promise as therapeutic agents. An underlying theme in the majority of recent peptoid research is the connection between peptoid function and peptoid structure. For certain applications, well-folded peptoids are essential for activity, while unstructured peptoids appear to suffice, or even are superior, for other applications. Currently, these structure-function connections are largely made after the design, synthesis, and characterization process. However, as guidelines for peptoid folding are elucidated and the known biological activities are expanded, we anticipate these connections will provide a pathway toward the de novo design of functional peptoids. In this perspective, we review several of the peptoid structure-function relationships that have been delineated over the past five years. Peptoids have emerged as a valuable class of foldamers for the study of biomolecular interactions and hold promise as therapeutic agents. This perspective analyzes the importance of peptoid structure in the discovery of biologically active peptoids over the past five years.
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影响因子：
--
作者：
Burkoth, TS;Beausoleil, E;Zuckermann, RN
通讯作者：
Zuckermann, RN
影响因子：
15
作者：
Hara, T;Durell, SR;Appella, DH
通讯作者：
Appella, DH
影响因子：
3.2
作者：
Holub, JM;Jang, HJ;Kirshenbaum, K
通讯作者：
Kirshenbaum, K
DOI：
10.1073/pnas.95.8.4309
发表时间：
1998-04-14
影响因子：
11.1
作者：
Armand, P;Kirshenbaum, K;Bradley, EK
通讯作者：
Bradley, EK
影响因子：
5.2
作者：
Gorske, BC;Jewell, SA;Blackwell, HE
通讯作者：
Blackwell, HE