Sex Differences in Thrombosis and Mortality in Patients Hospitalized for COVID-19.
Sex Differences in Thrombosis and Mortality in Patients Hospitalized for COVID-19.
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DOI：
10.1016/j.amjcard.2022.01.024
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发表时间：
2022-05-01
期刊：
影响因子：
--
通讯作者：
Berger JS
中科院分区：
文献类型：
--
作者：
Wilcox T;Smilowitz NR;Seda B;Xia Y;Hochman J;Berger JS
已有报道称，新冠肺炎患者住院期间血栓形成的性别差异。我们试图在新冠肺炎中调查年龄对性别与血栓形成或死亡的关系的影响。我们确定了从2020年3月1日到2020年4月17日在纽约一个大型医疗系统使用新冠肺炎住院的连续18岁的≥成年人。院内血栓形成和全因死亡率按性别和年龄分组进行评估。建立Logistic回归模型以估计多变量调整后血栓形成或死亡的几率。在3,334名因新冠肺炎入院的患者中，61%是男性。死亡或血栓形成在34%的住院患者中发生，在男性中更为常见(女性中36%对29%，P<；0.001；调整后的优势比[AOR]1.61，95%可信区间[CI]1.36至1.91)。当按年龄分层时，男性在年轻患者中死亡或血栓形成的发生率更高(18-54岁：21%比9%，AOR3.17，95%CI 2.06-5.01；55-74岁：39%比28%，AOR 1.63，95%CI 1.28-2.10)，但不是老年患者(≥75岁：55%比48%；AOR 1.20，95%CI 0.90-1.59)(交互作用p值：0.01)。就个体终点而言，男性比女性有更高的血栓形成风险(19%比12%；AOR 1.65，95%可信区间1.33至2.05)和死亡率(26%比23%；AOR 1.41，95%可信区间1.17至1.69)，性别差异随着年龄的增长而减弱。血栓形成和死亡率之间的关联在较年轻的患者中最为显著(年龄18-54岁，AOR8.25；年龄55-74岁，AOR2.38；年龄75岁，AOR1.88；P交互作用<；0.001)，但没有性别差异。总而言之，与女性相比，新冠肺炎患者血栓形成或死亡的风险更高，在年轻群体中最为明显。
Gender-specific differences in thrombosis have been reported in hospitalized patients with COVID-19. We sought to investigate the influence of age on the relation between gender and incident thrombosis or death in COVID-19. We identified consecutive adults aged ≥18 years hospitalized with COVID-19 from March 1, 2020, to April 17, 2020, at a large New York health system. In-hospital thrombosis and all-cause mortality were evaluated by gender and stratified by age group. Logistic regression models were generated to estimate the odds of thrombosis or death after multivariable adjustment. In 3,334 patients hospitalized with COVID-19, 61% were men. Death or thrombosis occurred in 34% of hospitalizations and was more common in men (36% vs 29% in women, p <0.001; adjusted odds ratio [aOR] 1.61, 95% confidence interval [CI] 1.36 to 1.91). When stratified by age, men had a higher incidence of death or thrombosis in younger patients (aged 18 to 54 years: 21% vs 9%, aOR 3.17, 95% CI 2.06 to 5.01; aged 55 to 74 years: 39% vs 28%, aOR 1.63, 95% CI 1.28 to 2.10), but not older patients (aged ≥75 years: 55% vs 48%; aOR 1.20, 95% CI 0.90 to 1.59) (interaction p value: 0.01). For the individual end points, men were at higher risk of thrombosis (19% vs 12%; aOR 1.65, 95% CI 1.33 to 2.05) and mortality (26% vs 23%; aOR 1.41, 95% CI 1.17 to 1.69) than women, and gender-specific differences were attenuated with older age. Associations between thrombosis and mortality were most striking in younger patients (aged 18 to 54 years, aOR 8.25; aged 55 to 74 years, aOR 2.38; aged >75 years, aOR 1.88; p for interaction <0.001) but did not differ by gender. In conclusion, the risk of thrombosis or death in COVID-19 is higher in men compared with women and is most apparent in younger age groups.
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影响因子：
11.1
作者：
Schmidt M;Horvath-Puho E;Thomsen RW;Smeeth L;Sørensen HT
通讯作者：
Sørensen HT
影响因子：
4.4
作者：
Zhou H;Hu Y;Li X;Wang L;Wang M;Xiao J;Yi Q
通讯作者：
Yi Q
DOI：
10.4049/jimmunol.1601896
发表时间：
2017-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Channappanavar R;Fett C;Mack M;Ten Eyck PP;Meyerholz DK;Perlman S
通讯作者：
Perlman S
影响因子：
8.9
作者：
Alkhouli, Mohamad;Nanjundappa, Aravinda;Bhatt, Deepak L.
通讯作者：
Bhatt, Deepak L.
影响因子：
100.3
作者：
Scully, Eileen P.;Haverfield, Jenna;Klein, Sabra L.
通讯作者：
Klein, Sabra L.