NONCODE v3.0: integrative annotation of long noncoding RNAs.
NONCODE v3.0: integrative annotation of long noncoding RNAs.
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NONCODE v3.0：长非编码RNA的综合注释
DOI：
10.1093/nar/gkr1175
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发表时间：
2012-01
影响因子：
14.9
通讯作者：
Zhao Y
中科院分区：
文献类型：
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作者：
Bu D;Yu K;Sun S;Xie C;Skogerbø G;Miao R;Xiao H;Liao Q;Luo H;Zhao G;Zhao H;Liu Z;Liu C;Chen R;Zhao Y
在高通量测序技术快速发展的推动下，近年来在哺乳动物转录组中发现了大量的长链非编码rna （lncRNAs）。LncRNAs已被证明在多种生物过程中发挥关键作用，如印迹控制、控制多能性和分化的电路、免疫反应和染色体动力学。值得注意的是，越来越多的lncrna与疾病病因学有关。随着lncRNA研究的不断发表，lncRNA的实验数据（表达谱、分子特征、生物学功能等）迅速积累。为了能够系统地编译和整合这些信息，我们将NONCODE数据库（http://www.noncode.org）更新到3.0版本，以包括第一个整合的表达和功能lncRNA数据集合，这些数据来自于一个数据库中重新注释的微阵列研究。NONCODE有一个用户友好的界面与各种搜索或浏览选项，本地基因组浏览器的可视化和BLAST服务器的序列比对搜索。此外，NONCODE为文献中报道的ncrna的持续整理提供了一个平台。NONCODE中的所有数据都对用户开放，可以通过网站下载或通过SOAP API和DAS服务获得。
Facilitated by the rapid progress of high-throughput sequencing technology, a large number of long noncoding RNAs (lncRNAs) have been identified in mammalian transcriptomes over the past few years. LncRNAs have been shown to play key roles in various biological processes such as imprinting control, circuitry controlling pluripotency and differentiation, immune responses and chromosome dynamics. Notably, a growing number of lncRNAs have been implicated in disease etiology. With the increasing number of published lncRNA studies, the experimental data on lncRNAs (e.g. expression profiles, molecular features and biological functions) have accumulated rapidly. In order to enable a systematic compilation and integration of this information, we have updated the NONCODE database (http://www.noncode.org) to version 3.0 to include the first integrated collection of expression and functional lncRNA data obtained from re-annotated microarray studies in a single database. NONCODE has a user-friendly interface with a variety of search or browse options, a local Genome Browser for visualization and a BLAST server for sequence-alignment search. In addition, NONCODE provides a platform for the ongoing collation of ncRNAs reported in the literature. All data in NONCODE are open to users, and can be downloaded through the website or obtained through the SOAP API and DAS services.
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影响因子：
56.9
作者：
Carninci, P;Kasukawa, T;Hayashizaki, Y
通讯作者：
Hayashizaki, Y
影响因子：
14.9
作者：
Kozomara A;Griffiths-Jones S
通讯作者：
Griffiths-Jones S
影响因子：
10.5
作者：
Cabili, Moran N.;Trapnell, Cole;Rinn, John L.
通讯作者：
Rinn, John L.
影响因子：
14.9
作者：
Pruitt KD;Tatusova T;Klimke W;Maglott DR
通讯作者：
Maglott DR
影响因子：
46.9
作者：
通讯作者：
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