Differences in platelet function in patients with acute myeloid leukemia and myelodysplasia compared to equally thrombocytopenic patients with immune thrombocytopenia.
Differences in platelet function in patients with acute myeloid leukemia and myelodysplasia compared to equally thrombocytopenic patients with immune thrombocytopenia.
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DOI：
10.1111/j.1538-7836.2011.04506.x
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Michelson AD
中科院分区：
文献类型：
--
作者：
Psaila B;Bussel JB;Frelinger AL;Babula B;Linden MD;Li Y;Barnard MR;Tate C;Feldman EJ;Michelson AD
Severe thrombocytopenia is a major risk factor for haemorrhage, and yet platelet function and bleeding risk at low platelet counts are poorly understood because of limitations of platelet function testing at very low platelet counts. To examine and compare platelet function in severely thrombocytopenic patients with acute myeloid leukaemia (AML) or myelodysplasia (MDS) to patients with immune thrombocytopenia (ITP). Whole blood flow cytometric measurement of platelet activation and platelet reactivity to agonists was correlated with the immature platelet fraction (IPF) and bleeding symptoms. Compared with patients with ITP, patients with AML/MDS had smaller platelets, lower IPF, and substantially lower platelet surface expression of activated GPIIb/IIIa and GPIb both with and without addition of ex vivo ADP or TRAP. In both ITP and AML/MDS, increased platelet surface GPIb on circulating platelets and expression of activated GPIIb/IIIa and GPIb on ex vivo activated platelets correlated with a higher IPF. Whereas platelet reactivity was higher for AML/MDS patients with bleeding than those with no bleeding, platelet reactivity was lower for ITP patients with bleeding than those with no bleeding. AML/MDS patients have lower in vivo platelet activation and ex vivo platelet reactivity than patients with ITP. The proportion of newly-produced platelets correlates with the expression of platelet surface markers of activation. These differences might contribute to differences in bleeding tendency between AML/MDS and ITP. This study is the first to define differences in platelet function between AML/MDS patients and ITP patients with equivalent degrees of thrombocytopenia.
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影响因子：
20.3
作者：
Psaila, Bethan;Petrovic, Aleksandra;Bussel, James B.
通讯作者：
Bussel, James B.
影响因子：
24
作者：
Gurbel, Paul A.;Becker, Richard C.;Michelson, Alan D.
通讯作者：
Michelson, Alan D.
影响因子：
15.9
作者：
KARPATKI.S
通讯作者：
KARPATKI.S
影响因子：
20.3
作者：
KESTIN, AS;VALERI, CR;MICHELSON, AD
通讯作者：
MICHELSON, AD
影响因子：
6.5
作者：
Page, Lemke K.;Psaila, Bethan;Bussel, James B.
通讯作者：
Bussel, James B.