Fear conditioning and extinction in alcohol dependence: Evidence for abnormal amygdala reactivity
Fear conditioning and extinction in alcohol dependence: Evidence for abnormal amygdala reactivity
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酒精依赖中的恐惧调节和消除：杏仁核反应异常的证据
DOI：
10.1111/adb.12835
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发表时间：
2019
影响因子：
3.4
通讯作者：
Lohoff FW
中科院分区：
文献类型：
--
作者：
Muench C;Charlet K;Balderston NL;Grillon C;Heilig M;Cortes CR;Momenan R;Lohoff FW
恐惧条件反射和消退（FCE）是适应性情绪调节的重要过程，在焦虑症中被破坏。尽管酒精依赖（ALC）和焦虑症之间存在实质性的共病，并且有报告称ALC中的负面情绪处理发生改变，但该临床人群中FCE的神经相关性仍然未知。在这里，我们在美国国立卫生研究院的43名健康参与者和43名ALC患者中使用了为期2天的恐惧学习范式。这项多模式研究的主要结果包括结构和功能脑磁共振成像，临床措施，以及皮肤电导反应（SCR），以确认差异条件反射。成功的FCE被证明在参与者的条件反射阶段的差异SCR和无差异的SCR条件刺激在消退阶段。ALC组在条件反射期间（Cohen'sd=.89，P（FWE）= .037）和恐惧更新期间（Cohen'sd=.68，P（FWE）= .039），右侧杏仁核的血氧水平依赖性反应显著降低。条件反射期间右侧杏仁核激活与ALC严重程度（r=.39，P（Bonferroni）= .009）、抑郁症状（r=.37，P（Bonferroni）= .015）、特质焦虑（r=.41，P（Bonferroni）= .006）和感知压力（r=.45，P（Bonferroni）= .002）显著相关。我们的数据表明，ALC患者在杏仁核中存在恐惧学习失调，特别是神经激活模式失调。此外，恐惧条件反射过程中杏仁核的激活与ALC相关的临床指标相关。FCE范式可能是一个很有前途的工具，调查参与负性情绪调节的结构，这可能会为ALC的新的治疗方法的发展提供信息。
Fear conditioning and extinction (FCE) are vital processes in adaptive emotion regulation and disrupted in anxiety disorders. Despite substantial comorbidity between alcohol dependence (ALC) and anxiety disorders and reports of altered negative emotion processing in ALC, neural correlates of FCE in this clinical population remain unknown. Here, we used a 2‐day fear learning paradigm in 43 healthy participants and 43 individuals with ALC at the National Institutes of Health. Main outcomes of this multimodal study included structural and functional brain magnetic resonance imaging, clinical measures, as well as skin conductance responses (SCRs) to confirm differential conditioning. Successful FCE was demonstrated across participants by differential SCRs in the conditioning phase and no difference in SCRs to the conditioned stimuli in the extinction phase. The ALC group showed significantly reduced blood oxygenation level‐dependent responses in the right amygdala during conditioning (Cohen'sd= .89,P(FWE)= .037) and in the left amygdala during fear renewal (Cohen'sd= .68,P(FWE)= .039). Right amygdala activation during conditioning was significantly correlated with ALC severity (r= .39,P(Bonferroni)= .009), depressive symptoms (r= .37,P(Bonferroni)= .015), trait anxiety (r= .41,P(Bonferroni)= .006), and perceived stress (r= .45,P(Bonferroni)= .002). Our data suggest that individuals with ALC have dysregulated fear learning, in particular, dysregulated neural activation patterns, in the amygdala. Furthermore, amygdala activation during fear conditioning was associated with ALC‐related clinical measures. The FCE paradigm may be a promising tool to investigate structures involved in negative affect regulation, which might inform the development of novel treatment approaches for ALC.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
6.9
作者：
Bremner, JD;Vermetten, E;Charney, DS
通讯作者：
Charney, DS
DOI：
--
发表时间：
2012
期刊：
--
影响因子：
--
作者：
M. Stephens;G. Wand
通讯作者：
M. Stephens;G. Wand
影响因子：
4.8
作者：
Bernstein, DP;Stein, JA;Zule, W
通讯作者：
Zule, W
DOI：
10.1111/j.1530-0277.2009.01026.x
发表时间：
2009-11
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Marinkovic K;Oscar-Berman M;Urban T;O'Reilly CE;Howard JA;Sawyer K;Harris GJ
通讯作者：
Harris GJ