Alcoholism and dampened temporal limbic activation to emotional faces.
Alcoholism and dampened temporal limbic activation to emotional faces.
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DOI：
10.1111/j.1530-0277.2009.01026.x
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Harris GJ
中科院分区：
文献类型：
--
作者：
Marinkovic K;Oscar-Berman M;Urban T;O'Reilly CE;Howard JA;Sawyer K;Harris GJ
长期过量饮酒会伴随着一系列情绪变化，从冷漠和情绪平淡到理解情绪信息的缺陷，但人们对它们的神经基础了解很少。通过功能磁共振成像检查了长期戒酒的酗酒男性的情绪异常，并与健康的人口学匹配的对照组进行了比较。在深层(语义)和浅层(知觉)编码任务中，参与者被呈现给他们情感上有价值的单词和面孔照片，然后再进行识别。总体而言，面孔比文字更能引起激活，具有预期的材料特定的偏侧性(左半球用于文字，右半球用于面孔)和深度加工效果。然而，尽管对照组参与者在观看情绪(相对于中性)表情的脸时，杏仁核和海马区表现出更强的激活，而酗酒者对所有面部表情的反应都是无差别的。在酗酒的参与者中，杏仁核的活动与作为其行为缺陷的函数的外侧前额叶活动的增加呈负相关。在与社会相关的面孔评估任务中，情绪功能的前额叶调节作为对迟钝的杏仁核活动的补偿与情绪面孔加工过程中的分布式网络参与是一致的。杏仁核和海马体的激活不足可能是与长期酒精中毒相关的情绪面孔加工障碍的基础，也可能是包括去抑制在内的一系列行为问题的一部分，同时存在以前在该人群中记录的人际关系困难。此外，研究结果表明，酗酒者可能依赖前额叶而不是颞叶边缘区域，以补偿边缘反应的减少，并在面临情绪或社会挑战的情况下保持行为充分性。
Excessive chronic drinking is accompanied by a broad spectrum of emotional changes ranging from apathy and emotional flatness to deficits in comprehending emotional information, but their neural bases are poorly understood. Emotional abnormalities associated with alcoholism were examined with functional magnetic resonance imaging in abstinent long-term alcoholic men in comparison to healthy demographically matched controls. Participants were presented with emotionally valenced words and photographs of faces during deep (semantic) and shallow (perceptual) encoding tasks followed by recognition. Overall, faces evoked stronger activation than words, with the expected material-specific laterality (left hemisphere for words, and right for faces) and depth of processing effects. However, whereas control participants showed stronger activation in the amygdala and hippocampus when viewing faces with emotional (relative to neutral) expressions, the alcoholics responded in an undifferentiated manner to all facial expressions. In the alcoholic participants, amygdala activity was inversely correlated with an increase in lateral prefrontal activity as a function of their behavioral deficits. Prefrontal modulation of emotional function as a compensation for the blunted amygdala activity during a socially relevant face appraisal task is in agreement with a distributed network engagement during emotional face processing. Deficient activation of amygdala and hippocampus may underlie impaired processing of emotional faces associated with long-term alcoholism and may be a part of the wide array of behavioral problems including disinhibition, concurring with previously documented interpersonal difficulties in this population. Furthermore, the results suggest that alcoholics may rely on prefrontal rather than temporal limbic areas in order to compensate for reduced limbic responsivity and to maintain behavioral adequacy when faced with emotionally or socially challenging situations.
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