CuInSe/ZnS core/shell NIR quantum dots for biomedical imaging.
CuInSe/ZnS core/shell NIR quantum dots for biomedical imaging.
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DOI：
10.1002/smll.201101558
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发表时间：
2011-11-18
期刊：
影响因子：
13.3
通讯作者：
Searson, Peter C.
中科院分区：
文献类型：
--
作者：
Park, Jeaho;Dvoracek, Charlene;Lee, Kwan Hyi;Galloway, Justin F.;Bhang, Hyo-eun C.;Pomper, Martin G.;Searson, Peter C.
A current challenge in biomedical imaging is the synthesis of water-soluble quantum dots (QDs) with emission wavelengths in the near-IR, a high quantum yield, stability in water, and relatively small sizes. Ideally the synthesis should be relatively straightforward and not involve toxic elements. The optimum wavelength for in-vivo optical imaging, taking into account the absorbance from melanin in the epidermis, hemoglobin in blood, and water in tissue, is in the range of 700-900 nm.[1, 2] To achieve emission in this optical window requires a QD with a bandgap of around 1.3–1.7 eV.[3] Semiconductor QDs that emit in the NIR—such as CdTe, PbS, InAs, InP—have been synthesized [4-8] and explored for biomedical imaging.[9-12] High quantum yield is important to optimize the signal-to-noise ratio for imaging, and stability in aqueous solutions is key to avoid aggregation and degradation during imaging. At the same time, it is thought that a hydrodynamic diameter less than about 15 nm is necessary to ensure renal clearance and to avoid accumulation in other organs.[13] In addition, due to concerns over toxicity if QDs are not cleared from the body, it is desirable to avoid elements such as cadmium, lead, and arsenic. Thus there remains a need for the development of QD systems that satisfy all of these requirements.
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