Seeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway.
Seeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway.
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DOI：
10.1016/j.pneurobio.2022.102252
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发表时间：
2022-05
影响因子：
6.7
通讯作者：
Ikemoto S
中科院分区：
文献类型：
--
作者：
Kesner AJ;Calva CB;Ikemoto S
强化学习和目标寻求行为被认为是由中脑多巴胺神经元介导的。然而，很少有人知道好奇心和探索性行为的神经基质，这发生在没有明确的目标或奖励。尽管行为科学家长期以来一直认为好奇心和探索行为是由先天驱动力调节的。我们将这种行为称为信息寻求行为，并提出1）关键神经基质和2）环境预测误差的概念作为理解信息寻求过程的框架。认知方面的信息寻求行为，包括感知的显着性和不确定性，涉及，部分，从后下丘脑乳头体上区到海马结构的途径。这种行为的活力受到以下因素的调节：乳头体上多巴胺能神经元;它们向内侧隔多巴胺能神经元的投射;以及内侧隔多巴胺能神经元向腹侧被盖多巴胺能神经元的投射。多巴胺能神经元的时相反应的特征在于信号潜在的重要刺激，而不是奖励。本文描述了新的刺激和不确定性如何触发寻求动机，以及这些神经基质如何调节信息寻求行为。
Reinforcement learning and goal-seeking behavior are thought to be mediated by midbrain dopamine neurons. However, little is known about neural substrates of curiosity and exploratory behavior, which occur in the absence of clear goal or reward. This is despite behavioral scientists having long suggested that curiosity and exploratory behaviors are regulated by an innate drive. We refer to such behavior as information-seeking behavior and propose 1) key neural substrates and 2) the concept of environment prediction error as a framework to understand information-seeking processes. The cognitive aspect of information-seeking behavior, including the perception of salience and uncertainty, involves, in part, the pathways from the posterior hypothalamic supramammillary region to the hippocampal formation. The vigor of such behavior is modulated by the following: supramammillary glutamatergic neurons; their projections to medial septal glutamatergic neurons; and the projections of medial septal glutamatergic neurons to ventral tegmental dopaminergic neurons. Phasic responses of dopaminergic neurons are characterized as signaling potentially important stimuli rather than rewards. This paper describes how novel stimuli and uncertainty trigger seeking motivation and how these neural substrates modulate information-seeking behavior.
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影响因子：
3.4
作者：
Keller, Kristine L.;Vollrath-Smith, Fiori R.;Jafari, Mehrnoosh;Ikemoto, Satoshi
通讯作者：
Ikemoto, Satoshi
影响因子：
56.9
作者：
Ahmadlou, Mehran;Houba, Janou H. W.;Heimel, J. Alexander
通讯作者：
Heimel, J. Alexander
影响因子：
3.5
作者：
Barter, Joseph W.;Li, Suellen;Yin, Henry H.
通讯作者：
Yin, Henry H.
影响因子：
16.6
作者：
Bender F;Gorbati M;Cadavieco MC;Denisova N;Gao X;Holman C;Korotkova T;Ponomarenko A
通讯作者：
Ponomarenko A
DOI：
10.1037/h0054977
发表时间：
1954-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BUTLER, RA;HARLOW, HF
通讯作者：
HARLOW, HF