Synergistic interaction between caloric restriction and amphetamine in food-unrelated approach behavior of rats.
Synergistic interaction between caloric restriction and amphetamine in food-unrelated approach behavior of rats.
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DOI：
10.1007/s00213-013-3300-9
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发表时间：
2014-03
影响因子：
3.4
通讯作者：
Ikemoto, Satoshi
中科院分区：
文献类型：
--
作者：
Keller, Kristine L.;Vollrath-Smith, Fiori R.;Jafari, Mehrnoosh;Ikemoto, Satoshi
关键词：
接近行为是由大脑整合有关环境和身体状态的信息来调节的。精神活性药物与这个过程相互作用。我们研究了热量（即食物）限制、安非他明和锂在增强运动活动和视觉刺激（VS）增强的反应中相互作用的程度，这是一种与能量稳态无关的奖励。大鼠要么随意获取食物，要么接受维持其原始体重 85-90% 的每日口粮。按下杠杆可打开提示灯 1 秒并关闭室内灯 5 秒。安非他明和锂分别通过腹腔注射和饮食给药。单独限制食物或苯丙胺（1 mg/kg）对 VS 强化反应几乎没有影响；然而，两种条件的结合显着增强了 VS 强化反应（4 倍）。需要持续 7 天或更长时间的食物限制才能增强安非他明对 VS 强化反应的作用。安非他明（0.3 – 3 mg/kg）在限制食物组和随意组之间类似地增强运动活性。重复注射安非他明可以使运动活动敏感，但不会使 VS 增强反应。此外，虽然长期锂治疗（0.2%碳酸锂饲料）减少了VS强化反应，但长期锂进一步增强了安非他明增强的VS强化反应。食物限制与精神活性药物相互作用，以比以前想象的更强大的方式增强与食物寻求无关的目标导向反应。锂可以增强安非他明的精神兴奋作用的新发现表明，在临床环境中将锂和精神兴奋药物联合使用时要谨慎。
Approach behavior is regulated by the brain integrating information about environment and body state. Psychoactive drugs interact with this process. We examined the extent to which caloric (i.e., food) restriction, amphetamine and lithium interact in potentiating locomotor activity and responding reinforced by visual stimulus (VS), a reward unrelated to energy homeostasis. Rats either had ad-libitum access to food or received daily rations that maintained 85-90% of their original body weights. Leverpressing turned on a cue light for 1 sec and turned off house light for 5 sec. Amphetamine and lithium were administered through intraperitoneal injections and diet, respectively. Food-restriction or amphetamine (1 mg/kg) alone had little effect on VS-reinforced responding; however, the combination of the two conditions markedly potentiated VS-reinforced responding (4-fold). Food restriction lasting 7 days or longer was needed to augment amphetamine’s effect on VS-reinforced responding. Amphetamine (0.3 – 3 mg/kg) potentiated locomotor activity similarly between food-restricted and ad-libitum groups. Repeated injections of amphetamine sensitized locomotor activity, but not VS-reinforced responding. In addition, while chronic lithium treatments (0.2% lithium carbonate chow) reduced VS-reinforced responding, chronic lithium further augmented amphetamine-potentiated VS-reinforced responding. Food-restriction interacts with psychoactive drugs to potentiate goal-directed responding unrelated to food-seeking in a much more powerful manner than previously thought. The novel finding that lithium can augment a psychostimulant effect of amphetamine suggests caution when combining lithium and psychostimulant drugs in clinical settings.
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影响因子：
4.7
作者：
Duchesne, Vincent;Boye, Sandra M.
通讯作者：
Boye, Sandra M.
影响因子：
2.9
作者：
Carr, KD
通讯作者：
Carr, KD
DOI：
10.6004/jnccn.2010.0068
发表时间：
2010-08-01
影响因子：
13.4
作者：
Breitbart, William;Alici, Yesne
通讯作者：
Alici, Yesne
影响因子：
1.9
作者：
Dickinson, A;Smith, J;Mirenowicz, J
通讯作者：
Mirenowicz, J
影响因子：
5.4
作者：
BINDRA, D
通讯作者：
BINDRA, D