Comparison of the PF07598-Encoded Virulence-Modifying Proteins of L. interrogans and L. borgpetersenii.
Comparison of the PF07598-Encoded Virulence-Modifying Proteins of L. interrogans and L. borgpetersenii.
复制标题
DOI：
10.3390/tropicalmed8010014
复制
发表时间：
2022-12-26
影响因子：
2.9
通讯作者：
Vinetz JM
中科院分区：
文献类型：
--
作者：
Vieira DS;Chaurasia R;Vinetz JM
钩端螺旋体病是一种新出现的传染病，暴发的频率和严重程度不断增加，高危人群的流行病学不断变化，并出现新的菌株、血清型、血清群和种属。由PF 07598基因家族编码的毒力修饰（VM）蛋白被假设为钩端螺旋体分泌的外毒素，介导严重和致命的钩端螺旋体病的分子和细胞发病机制。如果得到实验证实，这一概念将通过一系列新的靶向干预措施，彻底改变钩端螺旋体病的治疗、诊断、预后和疫苗介导的预防。VM蛋白与其他细菌分泌的蛋白外毒素一样，通过附着于真核细胞、与其他微生物竞争环境小生境中的有限资源、直接毒害靶细胞并破坏其在哺乳动物宿主中的功能来介导其毒力效应。与致病性最强的钩端螺旋体群，特别是L.问号线虫，其基因组含有12-15个PF 07598旁系同源物，家畜和人类病原体L. borgpetersenii有两个PF 07598旁系同源物。考虑到可能的非环境介导的传播一些L。然而，由于该种中存在Borgpetersenii菌株和数量少得多的VM蛋白，它们在感染和疾病中的作用可能与其他钩端螺旋体种完全不同。VM蛋白从致病性钩端螺旋体的不同分支的比较可能会加深我们对钩端螺旋体病的发病机制的理解，导致新的方法来改善钩端螺旋体感染的人类和动物。
Leptospirosis is an emerging infectious disease, with increasing frequency and severity of outbreaks, a changing epidemiology of populations at risk, and the emergence of new strains, serovars, serogroups, and species. Virulence-modifying (VM) proteins encoded by the PF07598 gene family are hypothesized to be Leptospira-secreted exotoxins that mediate the molecular and cellular pathogenesis of severe and fatal leptospirosis. If confirmed experimentally, this concept could revolutionize the treatment, diagnosis, prognosis, and vaccine-mediated prevention of leptospirosis by enabling a novel array of targeted interventions. VM proteins, as with other bacterial-secreted protein exotoxins, mediate their virulence effects by attaching to eukaryotic cells, competing with other microorganisms for limited resources in environmental niches, directly intoxicating target cells, and disrupting their function in the mammalian host. In contrast with the most pathogenic group of Lept ospira, particularly L. interrogans, whose genomes contain 12–15 PF07598 paralogs, strains of the livestock and human pathogen L. borgpetersenii have two PF07598 paralogs. Given the possible non-environmentally mediated transmission of some L. borgpetersenii strains and the much smaller number of VM proteins in this species, their role in infection and disease may well differ from other leptospiral species. Comparison of VM proteins from different clades of pathogenic Leptospira may deepen our understanding of leptospirosis’s pathogenesis, leading to novel approaches to ameliorating Leptospira infection in humans and animals.
登录
查看更多内容
影响因子：
7.3
作者：
Grassmann AA;Kremer FS;Dos Santos JC;Souza JD;Pinto LDS;McBride AJA
通讯作者：
McBride AJA
DOI：
10.4269/ajtmh.2011.11-0276
发表时间：
2011-09-01
影响因子：
3.3
作者：
Agampodi, Suneth B.;Peacock, Sharon J.;Vinetz, Joseph M.
通讯作者：
Vinetz, Joseph M.
DOI：
10.3390/ani12141788
发表时间：
2022-07-12
期刊：
Animals : an open access journal from MDPI
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.9
作者：
Gunnell, Mark K.;Robison, Richard A.;Adams, Byron J.
通讯作者：
Adams, Byron J.
LPS 诱导的预激活免疫反应可保护宿主免受钩端螺旋体病的侵害
影响因子：
3.7
作者：
Chen X;Xie X;Wu D;Zhang S;Zhang W;Cao Y
通讯作者：
Cao Y