Effect of Vaccination against Leptospira on Shelter Asymptomatic Dogs Following a Long-Term Study.
Effect of Vaccination against Leptospira on Shelter Asymptomatic Dogs Following a Long-Term Study.
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对收容所无症状犬只接种钩端螺旋体疫苗的长期研究
DOI：
10.3390/ani12141788
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发表时间：
2022-07-12
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
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众所周知，狗是钩端螺旋体的宿主，并且可以通过尿液成为钩端螺旋体的无症状携带者，将这种细菌传播到环境中，特别是在流行地区，这是一个严重的公共卫生问题。在这种情况下，狗的钩端螺旋体病疫苗接种是至关重要的长期保护对肾载体状态。研究共118只犬，为期365天，分为接种疫苗组（n = 94）和未接种疫苗组（n = 24）。A组再分为3组：A1组32只犬接种1号疫苗；A2由32只狗与#2；A3 30只狗与#3。进行血清学（MAT、IgG-ELISA）和尿PCR检测。疫苗接种后，血清反应性在D15时升高，且无论疫苗品牌如何，在D180前仍保持较高水平，在D30后抗体转为IgG。无论何种疫苗品牌，A组共有46.8%的动物至少一次pcr阳性，而B组为75%。(1)背景：狗的钩端螺旋体病疫苗接种是至关重要的，因为它们不仅要提供长期保护，而且要防止钩端螺旋体的肾载体状态。本研究评估了自然暴露于钩端螺旋体的狗接种疫苗后的体液反应及其对肾脏携带者状态的影响。(2)方法：对118只犬进行365 d的研究，分为A组（接种疫苗，n = 94）和B组（未接种疫苗，n = 24）。A组再分为3组：A1组32只犬接种1号疫苗；A2由32只狗与#2；A3 30只狗与#3。进行血清学（MAT、IgG-ELISA）和尿PCR检测。(3)结果：接种疫苗后，血清反应活性在D15时升高，且无论疫苗品牌如何，血清反应活性一直保持到D180，在D30后抗体转为IgG。A组46.8%的动物至少一次pcr阳性，而B组为75%，与疫苗品牌无关（p < 0.05; OR: 0.3）。(4)结论：所有商业化疫苗都成功地引发了基于igg的长期应答，并且在预防肾脏感染方面部分有效。
Dogs are known as hosts of Leptospira interrogans and can become asymptomatic carriers of leptospires in the urine, spreading this bacterium to the environment, especially in endemic areas, characterizing a serious public health problem. In this context, vaccination of dogs against leptospirosis is of paramount importance for long-term protection against renal carrier status. A total of 118 dogs were studied for 365 days, separated into Group A (vaccinated, n = 94) and Group B (non-vaccinated, n = 24). Group A was subdivided into three groups: A1 with 32 dogs immunized with the vaccine #1; A2 by 32 dogs with #2; and A3 30 dogs with #3. Serology (MAT and IgG-ELISA) and urinary PCR were conducted. Seroreactivity increased at D15 post-vaccination and, regardless of vaccine brand, remained high up to D180, with antibody switch to IgG after D30. A total of 46.8% of animals from Group A were PCR-positive at least once, in contrast to 75% in Group B, regardless of vaccine brand. (1) Background: Vaccination of dogs against leptospirosis is of paramount importance, as they ideally must provide not only long-term protection, but also against the renal carrier state of leptospires. This study assessed the post-vaccine humoral response against Leptospira in naturally exposed dogs and effects on renal carrier status. (2) Methods: A total of 118 dogs were studied for 365 days, separated into Group A (vaccinated, n = 94) and Group B (non-vaccinated, n = 24). Group A was subdivided into three groups: A1 with 32 dogs immunized with the vaccine #1; A2 by 32 dogs with #2; and A3 30 dogs with #3. Serology (MAT and IgG-ELISA) and urinary PCR were conducted. (3) Results: Seroreactivity increased at D15 post-vaccination and, regardless of vaccine brand, remained high up to D180, with antibody switch to IgG after D30. A total of 46.8% of animals from Group A were PCR-positive at least once, in contrast to 75% in Group B, regardless of vaccine brand (p < 0.05; OR: 0.3). (4) Conclusions: All commercial vaccines succeeded at eliciting a long-term IgG-based response and were partially effective at protecting against kidney infection.
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影响因子：
2.2
作者：
Klaasen, H. L. B. M.;van der Veen, M.;Sutton, D.
通讯作者：
Sutton, D.
影响因子：
1.8
作者：
Bouvet, J.;Cariou, C.;Guigal, P. M.
通讯作者：
Guigal, P. M.
DOI：
10.1590/s0037-86822011005000012
发表时间：
2011-04-01
影响因子：
2
作者：
Castro, Jacqueline Ribeiro de;Salaberry, Sandra Renata Sampaio;Lima-Ribeiro, Anna Monteiro Correia
通讯作者：
Lima-Ribeiro, Anna Monteiro Correia
DOI：
10.2460/javma.2003.222.1230
发表时间：
2003-05-01
期刊：
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
影响因子：
--
作者：
Harkin, KR;Roshto, YM;Chengappa, MM
通讯作者：
Chengappa, MM
影响因子：
2.6
作者：
Hartleben, Claudia P.;Leal, Fernanda M. A.;Dellagostin, Odir A.
通讯作者：
Dellagostin, Odir A.