Cancer: we should not forget the past.
Cancer: we should not forget the past.
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DOI：
10.7150/jca.10336
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发表时间：
2015
影响因子：
3.9
通讯作者：
Pulciani S
中科院分区：
文献类型：
--
作者：
Di Lonardo A;Nasi S;Pulciani S
癌症比人类存在的时间更长，自从人类出现在地球上以来，就一直面临着这种疾病。令人惊讶的是，仅在30年前就克隆了第一个人类癌症基因。这一点，以及分子癌症研究在过去30年中实现的其他非凡的科学目标，似乎表明对这种严重疾病的最终答案和解决方案已经找到。但事实并非如此，因为癌症仍有待战胜。要做到这一点，必须首先了解癌症。这篇综述强调了癌症的发生和发展是如何从古到今被解决的。旧的理论和成就提供了癌症认识的支柱，在奠定现代癌症研究的基础上进行了讨论。该综述强调了癌基因和抑癌基因的发现，强调了这些成就在癌症诊断和治疗中的关键作用。最后，本文还概述了现代技术如何促使人们急于加快这些目标的实现。
Cancer has been in existence longer than human beings, and man has been facing the illness ever since he made his appearance on Earth. Amazingly, the first human cancer gene was cloned only thirty years ago. This, and other extraordinary scientific goals achieved by molecular cancer research in the last 30 years, seems to suggest that definitive answers and solutions to this severe disease have been finally found. This was not the case, as cancer still remains to be defeated. To do so, cancer must be first understood. This review highlights how cancer onset and progression has been tackled from ancient times to present day. Old theories and achievements have provided the pillars of cancer understanding, in laying the basis of 'modern era' cancer research, are discussed. The review highlights the discovery of oncogenes and suppressor tumor genes, underlining the crucial role of these achievements in cancer diagnosis and therapies. Finally, an overview of how the modern technologies have given impetuous to expedite these goals is also considered.
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影响因子：
3.7
作者：
Chen Y;McGee J;Chen X;Doman TN;Gong X;Zhang Y;Hamm N;Ma X;Higgs RE;Bhagwat SV;Buchanan S;Peng SB;Staschke KA;Yadav V;Yue Y;Kouros-Mehr H
通讯作者：
Kouros-Mehr H
影响因子：
56.9
作者：
HUANG, HJS;YEE, JK;LEE, WH
通讯作者：
LEE, WH
影响因子：
3.9
作者：
Idikio HA
通讯作者：
Idikio HA
了解和靶向癌症干细胞：治疗意义和挑战
影响因子：
8.2
作者：
Chen, Ke;Huang, Ying-hui;Chen, Ji-long
通讯作者：
Chen, Ji-long
影响因子：
3.7
作者：
GRAHAM, FL;VANDEREB, AJ
通讯作者：
VANDEREB, AJ