Evaluating choices by single neurons in the frontal lobe: outcome value encoded across multiple decision variables.
Evaluating choices by single neurons in the frontal lobe: outcome value encoded across multiple decision variables.
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DOI：
10.1111/j.1460-9568.2009.06743.x
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Wallis JD
中科院分区：
文献类型：
--
作者：
Kennerley SW;Wallis JD
额叶的损伤会导致严重的决策障碍。一种可能的机制是，额叶皮层的神经元编码了许多变量，这些变量有助于评估选择，例如其成本，收益和成功的概率。然而，最佳决策要求人们不仅在面临选择时，而且在评估选择的结果时考虑这些变量，以便适当地适应未来的行为。为了研究额叶皮层在编码不同选择结果的价值中的作用，我们同时记录了前扣带皮层（ACC），眶额皮层（OFC）和外侧前额叶皮层（LPFC）中多个单神经元的活动，同时受试者评估了涉及概率，收益和成本操作的选择结果。额叶神经元对许多参数进行编码，这些参数使得能够计算这些变量的值，包括奖励的开始和偏移以及所执行的工作量，并且通常对多个决策变量的结果值进行编码。此外，许多神经元既编码任务选择阶段的预测结果，也编码任务结果阶段的经验结果。这些模式的选择性更普遍的ACC相对于OFC和LPFC。这些结果支持额叶皮层，主要是ACC，在选择方案之间进行选择，并评估该选择的结果，从而确保选择是最佳的和适应性的作用。
Damage to the frontal lobe can cause severe decision-making impairments. A mechanism that may underlie this is that neurons in the frontal cortex encode many variables that contribute to the valuation of a choice, such as its costs, benefits and probability of success. However, optimal decision-making requires that one considers these variables, not only when faced with the choice, but also when evaluating the outcome of the choice, in order to adapt future behaviour appropriately. To examine the role of the frontal cortex in encoding the value of different choice outcomes, we simultaneously recorded the activity of multiple single neurons in the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC) and lateral prefrontal cortex (LPFC) while subjects evaluated the outcome of choices involving manipulations of probability, payoff and cost. Frontal neurons encoded many of the parameters that enabled the calculation of the value of these variables, including the onset and offset of reward and the amount of work performed, and often encoded the value of outcomes across multiple decision variables. In addition, many neurons encoded both the predicted outcome during the choice phase of the task as well as the experienced outcome in the outcome phase of the task. These patterns of selectivity were more prevalent in ACC relative to OFC and LPFC. These results support a role for the frontal cortex, principally ACC, in selecting between choice alternatives and evaluating the outcome of that selection thereby ensuring that choices are optimal and adaptive.
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额叶中的神经元编码多个决策变量的值。
影响因子：
3.2
作者：
Kennerley SW;Dahmubed AF;Lara AH;Wallis JD
通讯作者：
Wallis JD
影响因子：
56.9
作者：
Ito, S;Stuphorn, V;Schall, JD
通讯作者：
Schall, JD
影响因子：
25
作者：
Morris, Genela;Nevet, Alon;Bergman, Hagai
通讯作者：
Bergman, Hagai
影响因子：
8.2
作者：
GEHRING, WJ;GOSS, B;DONCHIN, E
通讯作者：
DONCHIN, E
影响因子：
5.3
作者：
Hare, Todd A.;O'Doherty, John;Rangel, Antonio
通讯作者：
Rangel, Antonio