Differential effects of dorsomedial medulla lesion size on ingestive behavior in rats.
Differential effects of dorsomedial medulla lesion size on ingestive behavior in rats.
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背内侧髓质病变大小对大鼠摄入行为的不同影响。
DOI：
10.1152/ajpregu.1997.273.4.r1299
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Edwards,GL
中科院分区：
文献类型：
--
作者：
Wang,T;Edwards,GL
先前的研究表明，皮下注射异丙肾上腺素(Iso)或血管紧张素II治疗后，病变集中在最后区域(AP)的大鼠摄入更多的生理盐水和异常大量的水。此外，受损的大鼠在手术后立即体重显著下降。尽管如此，关于AP病变对液体摄入量和体重的影响，仍有不同的报道。这些报道表明，邻近的孤束核(NTS)可能在损伤后观察到的影响中发挥作用。在这项研究中，我们评估了不同病变大小对体重、液体摄入量和压力感受器反射的影响。由于病变中含有更多的NTS，对体重的影响较小。此外，随着NTS参与病变的增多，Iso引起的水摄入量也增加。相反，随着NTS更多地受累于病变，3h自由盐水摄入量和钠耗竭后的盐水摄入量减少。这些数据表明，与AP相邻的NTS中的神经细胞群可能在控制水和盐水摄取以及体重调节中发挥关键作用。
Previous studies indicate that rats with lesions centered on the area postrema (AP) drink more saline and consume abnormally large amounts of water after treatment with subcutaneous isoproterenol (Iso) or angiotensin II. In addition, lesioned rats lose a significant amount of body weight immediately after surgery. Nonetheless, there are disparate reports on the effects of lesions of the AP on fluid intake and body weight. These reports suggest that the adjacent nucleus of the solitary tract (NTS) may play a role in the effects observed subsequent to the lesion. In this study we evaluated the effects of varying lesion size on body weight, fluid intake, and the baroreflex. As the lesion included more of the NTS, the effect on body weight was reduced. Moreover, water intake induced by Iso increased as more NTS was involved in the lesion. Conversely, 3-h ad libitum saline intake and saline intake after sodium depletion decreased with more involvement of the NTS in the lesion. These data suggest that the neural population in the NTS bordering the AP may play a critical role in the control of water and saline intake as well as the regulation of body weight.
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