Geographic information systems and pharmacoepidemiology: using spatial cluster detection to monitor local patterns of prescription opioid abuse.
Geographic information systems and pharmacoepidemiology: using spatial cluster detection to monitor local patterns of prescription opioid abuse.
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DOI：
10.1002/pds.1939
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发表时间：
2010-06
影响因子：
2.6
通讯作者：
Butler, Stephen F.
中科院分区：
文献类型：
--
作者：
Brownstein, John S.;Green, Traci C.;Cassidy, Theresa A.;Butler, Stephen F.
了解地方一级类阿片滥用的空间分布情况可能有助于公共卫生干预措施。使用来自ASI-MV® Connect的新墨西哥州成瘾治疗机构的患者水平数据，我们将地理信息系统与空间扫描统计相结合，以生成处方阿片类药物滥用的风险地图，并识别特定产品和化合物滥用的集群。处方阿片类药物量数据用于确定所确定的类别是否超出了可用性的地理差异。收集了居住在新墨西哥州的24，452例患者的数据。在这些患者中，1779例（7.3%）报告滥用任何处方阿片类药物（过去30天）。根据阿片类药物类型，979例患者（4.0%）报告滥用任何氢可酮，1007例（4.1%）报告滥用任何羟考酮，108例（0.4%）报告滥用吗啡，507例（2.1%）报告滥用Vicodin®或等效仿制药，390例（1.6%）报告滥用奥施康定®，63例（0.2%）报告滥用MS Contin®或等效仿制药。在阿尔伯克基周围地区发现的滥用率最高，每100名受访患者中有8.6名患者表示滥用。我们发现滥用聚集在阿尔伯克基周围（P=0.001;相对风险=1.35，半径为146公里）。在化合物水平上，我们发现药物可用性是处方阿片类药物滥用聚集的部分原因。考虑药物可用性后，我们在新墨西哥州拉斯克鲁塞斯和得克萨斯州埃尔帕索附近的南部农村地区以及与墨西哥接壤的地区确定了第二个Vicodin®滥用集中地（RR=2.1; P=0.001）。更好地了解当地的风险分布可能对今后引进处方类阿片的应对战略产生影响。
Understanding the spatial distribution of opioid abuse at the local level may facilitate public health interventions. Using patient-level data from addiction treatment facilities in New Mexico from ASI-MV® Connect, we applied geographic information system in combination with a spatial scan statistics to generate risk maps of prescription opioid abuse and identify clusters of product- and compound-specific abuse. Prescribed opioid volume data was used to determine whether identified clusters are beyond geographic differences in availability. Data on 24,452 patients residing in New Mexico was collected. Among those patients, 1779 (7.3%) reported abusing any prescription opioid (past 30 days). According to opioid type, 979 patients (4.0%) reported abuse of any hydrocodone, 1007 (4.1%) for any oxycodone, 108 (0.4%) for morphine, 507 (2.1%) for Vicodin® or generic equivalent, 390 (1.6%) for OxyContin®, and 63 (0.2%) for MS Contin® or generic equivalent. Highest rates of abuse were found in the area surrounding Albuquerque with 8.6 patients indicating abuse per 100 interviewed patients. We found clustering of abuse around Albuquerque (P=0.001; Relative Risk=1.35 and a radius of 146 km). At the compound level, we found that drug availability was partly responsible for clustering of prescription opioid abuse. After accounting for drug availability, we identified a second foci of Vicodin® abuse in the southern rural portion of the state near Las Cruces, NM and El Paso, Texas and bordering Mexico (RR=2.1; P=0.001). A better understanding of local risk distribution may have implications for response strategies to future introductions of prescription opioids.
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影响因子：
--
作者：
DWASS, M
通讯作者：
DWASS, M
影响因子：
0.8
作者：
Kulldorff, M
通讯作者：
Kulldorff, M
影响因子：
2.1
作者：
Brownstein, John S.;Rosen, Hilary;Fish, Durland
通讯作者：
Fish, Durland
影响因子：
5.5
作者：
Glass, GE
通讯作者：
Glass, GE
DOI：
10.1196/annals.1316.055
发表时间：
2004-01-01
期刊：
CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY
影响因子：
--
作者：
Kulsudjarit, K
通讯作者：
Kulsudjarit, K