White matter injury in ischemic stroke.
White matter injury in ischemic stroke.
复制标题
DOI：
10.1016/j.pneurobio.2016.04.005
复制
发表时间：
2016-06
影响因子：
6.7
通讯作者：
Cao G
中科院分区：
文献类型：
--
作者：
Wang Y;Liu G;Hong D;Chen F;Ji X;Cao G
中风是世界范围内致残和死亡的主要原因之一。众所周知，缺血性脑卒中可引起脑灰质损伤。然而，卒中也会引起严重的白色损伤，这是卒中发生率较高和神经功能预后不良的危险因素。中风引起的大部分损伤位于皮层下区域，值得注意的是，白色物质占据了平均梗死体积的近一半。事实上，白色物质极易受到缺血的影响，而且往往比灰质受到更严重的损伤。与白色物质损伤相关的临床症状包括认知功能障碍、情绪障碍、感觉运动障碍以及尿失禁和疼痛，所有这些都与白色物质连接的破坏和重塑密切相关。白色物质损伤可以通过MRI无创检测，其提供了其形态、代谢和功能的三维评估。迫切需要新的白色物质疗法，因为目前可用的策略仅限于临床前动物研究。预防缺血性卒中的最佳保护措施需要同时强化灰质和白色物质。在这篇综述中，我们讨论了缺血性卒中后的白色损伤，重点是临床特征和工具，如影像学，表现和潜在的治疗。我们还简要讨论了脑梗死的病理生理学和未来的研究方向。
Stroke is one of the major causes of disability and mortality worldwide. It is well known that ischemic stroke can cause gray matter injury. However, stroke also elicits profound white matter injury, a risk factor for higher stroke incidence and poor neurological outcomes. The majority of damage caused by stroke is located in subcortical regions and, remarkably, white matter occupies nearly half of the average infarct volume. Indeed, white matter is exquisitely vulnerable to ischemia and is often injured more severely than gray matter. Clinical symptoms related to white matter injury include cognitive dysfunction, emotional disorders, sensorimotor impairments, as well as urinary incontinence and pain, all of which are closely associated with destruction and remodeling of white matter connectivity. White matter injury can be noninvasively detected by MRI, which provides a three-dimensional assessment of its morphology, metabolism, and function. There is an urgent need for novel white matter therapies, as currently available strategies are limited to preclinical animal studies. Optimal protection against ischemic stroke will need to encompass the fortification of both gray and white matter. In this review, we discuss white matter injury after ischemic stroke, focusing on clinical features and tools, such as imaging, manifestation, and potential treatments. We also briefly discuss the pathophysiology of WMI and future research directions.
登录
查看更多内容
影响因子：
8.2
作者：
Cho AH;Kim HR;Kim W;Yang DW
通讯作者：
Yang DW
影响因子：
6.3
作者：
Campos, Francisco;Sobrino, Tomas;Castillo, Jose
通讯作者：
Castillo, Jose
影响因子：
6.3
作者：
Cheng, Bastian;Schulz, Robert;Thomalla, Goetz
通讯作者：
Thomalla, Goetz
影响因子：
11.2
作者：
Alix, James J. P.;Fern, Robert
通讯作者：
Fern, Robert
影响因子：
5.3
作者：
Baltan, Selva;Besancon, Elaine F.;Ransom, Bruce R.
通讯作者：
Ransom, Bruce R.