Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungs.
Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungs.
复制标题
DOI：
10.1007/s10585-009-9262-y
复制
发表时间：
2009
影响因子：
4
通讯作者：
Palti, Yoram
中科院分区：
文献类型：
--
作者：
Kirson, Eilon D.;Giladi, Moshe;Gurvich, Zoya;Itzhaki, Aviran;Mordechovich, Daniel;Schneiderman, Rosa S.;Wasserman, Yoram;Ryffel, Bernhard;Goldsher, Dorit;Palti, Yoram
肿瘤治疗场 (TTField) 是用于治疗癌性肿瘤的低强度、中频交变电场。这种新颖的治疗方式可有效抑制体内实体瘤的生长，并在晚期实体瘤患者的试点临床试验中显示出前景。在两种动物模型中测试了 TTField 抑制实体瘤向肺部转移扩散的潜力：(1) 将恶性黑色素瘤细胞 (B16F10) 注射到尾静脉的小鼠，(2) 在肾囊内植入 VX-2 肿瘤的新西兰白兔。使用 100–200 kHz 的双向 TTFields 治疗小鼠和兔子。监测动物的存活情况，或处死动物以进行肺部病理和组织学分析。 TTFields 治疗小鼠的肺表面转移总数和肺绝对重量均显着低于假手术对照组小鼠。 TTFields 处理的兔子比假手术对照动物的存活时间更长。研究发现，与对照组相比，TTFields 治疗兔肺部的转移扩散、播种或生长受到抑制，从而延长了生存期。组织学上，仅在 TTFields 处理的兔子中观察到广泛的肿瘤周围和肿瘤内免疫细胞浸润。这些结果提出了一种可能性：除了已证实的对实体瘤生长的抑制作用之外，TTFields 还可能在预防原发性肿瘤的转移性扩散方面具有临床益处。
Tumor treating fields (TTFields) are low intensity, intermediate frequency, alternating electric fields used to treat cancerous tumors. This novel treatment modality effectively inhibits the growth of solid tumors in vivo and has shown promise in pilot clinical trials in patients with advanced stage solid tumors. TTFields were tested for their potential to inhibit metastatic spread of solid tumors to the lungs in two animal models: (1) Mice injected with malignant melanoma cells (B16F10) into the tail vein, (2) New Zealand White rabbits implanted with VX-2 tumors within the kidney capsule. Mice and rabbits were treated using two-directional TTFields at 100–200 kHz. Animals were either monitored for survival, or sacrificed for pathological and histological analysis of the lungs. The total number of lung surface metastases and the absolute weight of the lungs were both significantly lower in TTFields treated mice then in sham control mice. TTFields treated rabbits survived longer than sham control animals. This extension in survival was found to be due to an inhibition of metastatic spread, seeding or growth in the lungs of TTFields treated rabbits compared to controls. Histologically, extensive peri- and intra-tumoral immune cell infiltration was seen in TTFields treated rabbits only. These results raise the possibility that in addition to their proven inhibitory effect on the growth of solid tumors, TTFields may also have clinical benefit in the prevention of metastatic spread from primary tumors.
登录
查看更多内容
影响因子：
4.5
作者：
Nakada, SY;Jerde, TJ;Lee, FT
通讯作者：
Lee, FT
影响因子：
8
作者：
Whiteside, T. L.
通讯作者：
Whiteside, T. L.
影响因子：
4.8
作者：
Hayes, AL;Smith, C;Brennan, FM
通讯作者：
Brennan, FM
影响因子：
5
作者：
vanSonnenberg, E;Shankar, S;Sugarbaker, DJ
通讯作者：
Sugarbaker, DJ
影响因子：
9.8
作者：
WALTON, B
通讯作者：
WALTON, B