Personalized Low-Energy Defibrillation Through Feedback Based Resynchronization Therapy.
Personalized Low-Energy Defibrillation Through Feedback Based Resynchronization Therapy.
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DOI：
10.22489/cinc.2020.471
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Fenton FH
中科院分区：
文献类型：
--
作者：
Uzelac I;Fenton FH
除颤电击可能导致房室结烧坏、瘢痕形成和疼痛。在这项研究中，我们提出了一个实时的反馈为基础的控制室颤（VF）与一系列的低能量冲击使用心室电活动作为反馈输入。Langendorff灌注离体兔心脏并用荧光Vm染料染色。心室活动由一对光电二极管测量，并由反馈控制器处理以实时计算除颤电击参数。电击定时基于VF期间左心室和右心室的去极化激活，并且强度与光电二极管信号的幅度差成比例。使用定制开发的任意波形跨导放大器进行电击。与单次双相电击相比，基于反馈的除颤治疗在窦性心律恢复之前将VT转化为MT，同时减少除颤能量。基于反馈的电击疗法基于心室活动的实时感测，同时递送一系列低能量电击，从而降低相关副作用的风险。
Defibrillation shocks may cause AV node burnout, scar formation, and pain. In this study, we present a real-time feedback-based control of ventricular fibrillation (VF) with a series of low-energy shocks using ventricular electrical activity as the feedback input. Isolated rabbit hearts were Langendorff perfused and stained with a fluorescent Vm dye. The ventricular activity was measured with a pair of photodiodes, and processed with a feedback controller to calculate defibrillation shock parameters in real-time. Shock timing was based on desynchronized activation of the left and right ventricles during VF, and the strength was proportional to the amplitude difference of the photodiode signals. Shocks were delivered with a custom-developed arbitrary waveform trans-conductance amplifier. Feedback based resynchronization therapy converts VT to MT before sinus rhythm is restored with a reduction of defibrillation energy, compared to a single biphasic shock. Feedback based resynchronization therapy is based on real-time sensing of ventricular activity, while a series of low-energy shocks are delivered, reducing the risk of associated side effects.
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影响因子：
2.9
作者：
Garzon, Alejandro;Grigoriev, Roman O.;Fenton, Flavio H.
通讯作者：
Fenton, Flavio H.
影响因子：
6.2
作者：
Gerstein, Neal S.;McLean, A. Robb;Schulman, Peter M.
通讯作者：
Schulman, Peter M.
影响因子：
8.8
作者：
Marn-Pernat, A;Weil, MH;Bisera, J
通讯作者：
Bisera, J
影响因子：
5.5
作者：
Claire, Yanyan;Uzelac, Ilija;Fenton, Flavio H.
通讯作者：
Fenton, Flavio H.
影响因子：
10.8
作者：
HOLLEY, LK;MCCULLOCH, RM
通讯作者：
MCCULLOCH, RM