Measurement of infarct size and percentage myocardium infarcted in a dog preparation with single photon-emission computed tomography, thallium-201, and indium 111-monoclonal antimyosin Fab.
Measurement of infarct size and percentage myocardium infarcted in a dog preparation with single photon-emission computed tomography, thallium-201, and indium 111-monoclonal antimyosin Fab.
复制标题
使用单光子发射计算机断层扫描、铊 201 和铟 111 单克隆抗肌球蛋白 Fab 测量狗制剂中的梗塞面积和心肌梗塞百分比。
作者：
L. Johnson;K. Lerrick;J. Coromilas;D. Seldin;P. Esser;J. Zimmerman;A. Keller;P. Alderson;J. Bigger;P. Cannon
单光子发射断层扫描（SPECT）和铟111标记的单克隆抗肌球蛋白Fab片段被用来测量心肌梗死的大小在12只狗，6个受到球囊导管诱导的冠状动脉闭塞6小时（晚期再灌注）和6个受到闭塞与再灌注2小时（早期再灌注）。在静脉内注射标记的Fab片段后24小时，使用具有中等能量准直器的双头SPECT照相机进行断层成像。第一次断层扫描后，立即向12只狗中的9只注射铊-201，并重复成像。估计的梗死面积（克）是根据经轴向重建、标准化和背景校正的铟SPECT图像计算的，并使用阈值技术进行边缘检测。通过类似的方法从倾斜重建的铊SPECT图像计算估计的非梗死心肌（克）。处死动物，通过氯化三苯基四唑染色测量梗死面积（克）和真实梗死面积（占左心室心肌总体积的百分比）。从铟SPECT图像估计的梗死面积显示出与真实梗死面积的良好相关性（r = 0.95，SEE = 4.1 g）。估计的心肌梗死百分比通过将铟图像估计的梗死面积除以估计的梗死面积加上从铊图像获得的估计的非梗死心肌的总和来计算。心肌梗死的估计百分比与心肌梗死的真实百分比之间的相关性极佳（r = 0.93，SEE = 4.4%）。我们的结论是，双同位素SPECT与铟111单克隆抗肌球蛋白抗体和铊-201可以准确地估计梗死面积和心肌梗死的百分比。
Single photon-emission tomography (SPECT) and indium 111-labeled monoclonal antimyosin Fab fragments were used to measure myocardial infarct size in 12 dogs, six subjected to balloon catheter-induced coronary artery occlusion for 6 hr (late reperfusion) and six subjected to occlusion with reperfusion at 2 hr (early reperfusion). Tomographic imaging was performed 24 hr after the intravenous injection of labeled Fab fragments with the use of a dual-head SPECT camera with medium-energy collimators. Immediately after the first tomographic scan, thallium-201 was injected into nine of 12 dogs and imaging was repeated. Estimated infarct size in grams was calculated from transaxially reconstructed, normalized, and background-corrected indium SPECT images with the use of a threshold technique for edge detection. Estimated noninfarcted myocardium in grams was calculated from obliquely reconstructed thallium SPECT images by a similar method. The animals were killed and infarct size in grams and true infarct size as a percentage of total left ventricular myocardial volume were measured by triphenyl tetrazolium chloride staining. Estimated infarct size from indium SPECT images showed an excellent correlation with true infarct size (r = .95, SEE = 4.1 g). Estimated percentage myocardium infarcted was calculated by dividing estimated infarct size from indium images by the sum of estimated infarct size plus estimated noninfarcted myocardium obtained from thallium images. Correlation between the estimated percentage of myocardium infarcted and true percentage of myocardium infarcted was excellent (r = .93, SEE = 4.4%). We conclude that dual-isotope SPECT with indium 111-monoclonal antimyosin antibodies and thallium-201 can accurately estimate infarct size and percentage myocardium infarcted.
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影响因子：
37.8
作者：
W. Schaper;S. Pasyk
通讯作者：
W. Schaper;S. Pasyk
使用 201 铊进行单光子发射计算机断层扫描测定左心室质量。
DOI：
10.1016/0002-9149(84)90095-x
发表时间：
1984
期刊：
The American journal of cardiology
影响因子：
--
作者：
Wolfe,CL;Corbett,JR;Lewis,SE;Buja,LM;Willerson,JT
通讯作者：
Willerson,JT
使用单光子发射计算机断层扫描测量心肌梗死分数。
影响因子：
24
作者：
Wolfe,CL;Lewis,SE;Corbett,JR;Parkey,RW;Buja,LM;Willerson,JT
通讯作者：
Willerson,JT
使用 99m 焦磷酸锝进行单光子发射计算机断层扫描测量急性犬心肌梗塞的梗塞面积。
DOI：
10.1016/0002-9149(84)90328-x
发表时间：
1984
期刊：
The American journal of cardiology
影响因子：
--
作者：
Lewis,SE;DevousSr,MD;Corbett,JR;Izquierdo,C;Nicod,P;Wolfe,CL;Parkey,RW;Buja,LM;Willerson,JT
通讯作者：
Willerson,JT
影响因子：
--
作者：
B. Khaw;J. Mattis;G. Melincoff;H. Strauss;H. Gold;E. Haber
通讯作者：
B. Khaw;J. Mattis;G. Melincoff;H. Strauss;H. Gold;E. Haber