Generalizable cursor click decoding using grasp-related neural transients.
Generalizable cursor click decoding using grasp-related neural transients.
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DOI:
10.1088/1741-2552/ac16b2
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发表时间:
2021-08-31
影响因子:
4
通讯作者:
Collinger JL
中科院分区:
文献类型:
--
作者:
Dekleva BM;Weiss JM;Boninger ML;Collinger JL
Intracortical brain-computer interfaces (iBCI) have the potential to restore independence for individuals with significant motor or communication impairments. One of the most realistic avenues for clinical translation of iBCI technology is enabling control of a computer cursor—i.e. movement-related neural activity is interpreted (decoded) and used to drive cursor function. Here we aim to improve cursor click decoding to allow for both point-and-click and click-and-drag control. Using chronic microelectrode arrays implanted in the motor cortex of two participants with tetraplegia, we identified prominent neural responses related to attempted hand grasp. We then developed a new approach for decoding cursor click (hand grasp) based on the most salient responses. We found that the population-wide response contained three dominant components related to hand grasp: an onset transient response, a sustained response, and an offset transient response. The transient responses were larger in magnitude—and thus more reliably detected—than the sustained response, and a click decoder based on these transients outperformed the standard approach of binary state classification. A transient-based approach for identifying hand grasp can provide a high degree of cursor click control for both point-and-click and click-and-drag applications. This generalized click functionality is an important step toward high-performance cursor control and eventual clinical translation of iBCI technology.
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影响因子:
4
作者:
Sachs NA;Ruiz-Torres R;Perreault EJ;Miller LE
通讯作者:
Miller LE
影响因子:
64.8
作者:
Ethier, C.;Oby, E. R.;Bauman, M. J.;Miller, L. E.
通讯作者:
Miller, L. E.
影响因子:
17.1
作者:
Jarosiewicz B;Sarma AA;Bacher D;Masse NY;Simeral JD;Sorice B;Oakley EM;Blabe C;Pandarinath C;Gilja V;Cash SS;Eskandar EN;Friehs G;Henderson JM;Shenoy KV;Donoghue JP;Hochberg LR
通讯作者:
Hochberg LR
影响因子:
2.5
作者:
Sergio, LE;Kalaska, JF
通讯作者:
Kalaska, JF
影响因子:
4.1
作者:
Ryu SI;Shenoy KV
通讯作者:
Shenoy KV