The temporal lag structure of short-term associations of fine particulate matter chemical constituents and cardiovascular and respiratory hospitalizations.
The temporal lag structure of short-term associations of fine particulate matter chemical constituents and cardiovascular and respiratory hospitalizations.
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DOI：
10.1289/ehp.1104721
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发表时间：
2012-08
影响因子：
10.4
通讯作者：
Vedal S
中科院分区：
文献类型：
--
作者：
Kim SY;Peel JL;Hannigan MP;Dutton SJ;Sheppard L;Clark ML;Vedal S
背景：在空气污染的时间序列研究中，精细特定物质的临时模式（PM2.5；颗粒物质≤2.5µm空气动力学的直径）和健康终点的临界点因疾病类别而变化。
目标：我们在丹佛气溶胶来源和健康（DASH）研究中使用每日PM2.5化学构建数据（DASH）研究探索了住院的滞后结构。
方法：从2003年到2007年，我们测量了PM2.5的构造，包括元素，硫酸盐和硝酸盐，并将这些日常污染数据与五县丹佛大都会区域的五县丹佛大都会区域的医院录取和呼吸道的呼吸道相对率相关联。 PM2.5和4的医院入院在同一天，从约束分布式滞后模型的1到14天构成。
结果：对于总心血管入院的较短滞后时，RR通常是较长的滞后滞后滞后滞后滞后的滞后滞后。
结论：总的来说，PM2.5化学一致性对心血管疾病具有更直接的估计作用，并且对呼吸道疾病的估计影响更大，具体取决于某些构成物。
Background: In air pollution time-series studies, the temporal pattern of the association of fine particulate matter (PM2.5; particulate matter ≤ 2.5 µm in aerodynamic diameter) and health end points has been observed to vary by disease category. The lag pattern of PM2.5 chemical constituents has not been well investigated, largely because daily data have not been available. Objectives: We explored the lag structure for hospital admissions using daily PM2.5 chemical constituent data for 5 years in the Denver Aerosol Sources and Health (DASH) study. Methods: We measured PM2.5 constituents, including elemental carbon, organic carbon, sulfate, and nitrate, at a central residential site from 2003 through 2007 and linked these daily pollution data to daily hospital admission counts in the five-county Denver metropolitan area. Total hospital admissions and subcategories of respiratory and cardiovascular admissions were examined. We assessed the lag structure of relative risks (RRs) of hospital admissions for PM2.5 and four constituents on the same day and from 1 to 14 previous days from a constrained distributed lag model; we adjusted for temperature, humidity, longer-term temporal trends, and day of week using a generalized additive model. Results: RRs were generally larger at shorter lags for total cardiovascular admissions but at longer lags for total respiratory admissions. The delayed lag pattern was particularly prominent for asthma. Elemental and organic carbon generally showed more immediate patterns, whereas sulfate and nitrate showed delayed patterns. Conclusion: In general, PM2.5 chemical constituents were found to have more immediate estimated effects on cardiovascular diseases and more delayed estimated effects on respiratory diseases, depending somewhat on the constituent.
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影响因子：
5
作者：
Dutton, Steven J.;Vedal, Sverre;Piedrahita, Ricardo;Milford, Jana B.;Miller, Shelly L.;Hannigan, Michael P.
通讯作者：
Hannigan, Michael P.
细颗粒空气污染的成分对加利福尼亚州死亡率的影响：钙钙的结果。
影响因子：
10.4
作者：
Ostro, Bart;Feng, Wen-Ying;Broadwin, Rachel;Green, Shelley;Lipsett, Michael
通讯作者：
Lipsett, Michael
影响因子：
5.4
作者：
Schwartz, J
通讯作者：
Schwartz, J
影响因子：
120.7
作者：
Dominici, F;Peng, RD;Samet, JM
通讯作者：
Samet, JM
影响因子：
10.4
作者：
Ito K;Mathes R;Ross Z;Nádas A;Thurston G;Matte T
通讯作者：
Matte T