Fine particulate matter constituents associated with cardiovascular hospitalizations and mortality in New York City.
Fine particulate matter constituents associated with cardiovascular hospitalizations and mortality in New York City.
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DOI：
10.1289/ehp.1002667
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发表时间：
2011-04
影响因子：
10.4
通讯作者：
Matte T
中科院分区：
文献类型：
--
作者：
Ito K;Mathes R;Ross Z;Nádas A;Thurston G;Matte T
最近的时间序列研究表明，心血管疾病（CVD）死亡率和住院治疗与颗粒物（PM）有关。然而，PM协会与这些结果的季节性模式是不一致的，和PM组件负责这些协会尚未确定。我们在纽约市（NYC）调查了这一问题，PM来源于区域和当地的燃烧源。在这项研究中，我们研究了空气动力学直径≤ 2.5 μm的颗粒物（PM2.5）及其关键化学成分对纽约市CVD住院和死亡率的作用。我们分析了2000-2006年≥ 40岁人群中每日死亡和心血管疾病急诊住院与PM2.5、其化学成分、二氧化氮（NO2）、一氧化碳和二氧化硫的相关性，使用Poisson时间序列模型调整时间和季节趋势、温度效应和星期几。我们估计了温暖季节（4月至9月）和寒冷季节（10月至3月）在滞后0至3天的每个四分位数范围增加的超额风险。心血管疾病死亡率系列显示出强烈的季节性趋势，而心血管疾病住院系列显示出强烈的一周一天的模式。这些结果系列彼此之间没有相关性，但与区域和当地来源的一些PM2.5化学成分单独相关，每个成分都具有不同的季节模式和滞后。与煤燃烧有关的成分（例如，硒）与夏季的心血管疾病死亡率和冬季的心血管疾病住院率相关，而元素碳和NO2在两个季节都与这些结果相关。当地的燃烧源，包括交通和残油燃烧，可能在空气污染和CVD结果之间的关联中发挥全年的作用，但输送的气溶胶可以解释PM2.5质量所示的关联的季节性变化。
Recent time-series studies have indicated that both cardiovascular disease (CVD)mortality and hospitalizations are associated with particulate matter (PM). However, seasonal patterns of PM associations with these outcomes are not consistent, and PM components responsible for these associations have not been determined. We investigated this issue in New York City (NYC), where PM originates from regional and local combustion sources. In this study, we examined the role of particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5) and its key chemical components on both CVD hospitalizations and on mortality in NYC. We analyzed daily deaths and emergency hospitalizations for CVDs among persons ≥ 40 years of age for associations with PM2.5, its chemical components, nitrogen dioxide (NO2), carbon monoxide, and sulfur dioxide for the years 2000–2006 using a Poisson time-series model adjusting for temporal and seasonal trends, temperature effects, and day of the week. We estimated excess risks per interquartile-range increases at lags 0 through 3 days for warm (April through September) and cold (October through March) seasons. The CVD mortality series exhibit strong seasonal trends, whereas the CVD hospitalization series show a strong day-of-week pattern. These outcome series were not correlated with each other but were individually associated with a number of PM2.5 chemical components from regional and local sources, each with different seasonal patterns and lags. Coal-combustion–related components (e.g., selenium) were associated with CVD mortality in summer and CVD hospitalizations in winter, whereas elemental carbon and NO2 showed associations with these outcomes in both seasons. Local combustion sources, including traffic and residual oil burning, may play a year-round role in the associations between air pollution and CVD outcomes, but transported aerosols may explain the seasonal variation in associations shown by PM2.5 mass.
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影响因子：
10.4
作者：
Ostro, Bart;Feng, Wen-Ying;Broadwin, Rachel;Green, Shelley;Lipsett, Michael
通讯作者：
Lipsett, Michael
影响因子：
10.4
作者：
Samoli, Evangelia;Peng, Roger;Ramsay, Tim;Pipikou, Marina;Touloumi, Giota;Dominici, Francesca;Burnett, Rick;Cohen, Aaron;Krewski, Daniel;Samet, Jon;Katsouyanni, Klea
通讯作者：
Katsouyanni, Klea
影响因子：
10.4
作者：
Peng RD;Bell ML;Geyh AS;McDermott A;Zeger SL;Samet JM;Dominici F
通讯作者：
Dominici F
DOI：
10.1097/ede.0b013e3181812bb7
发表时间：
2008-09
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Franklin M;Koutrakis P;Schwartz P
通讯作者：
Schwartz P
影响因子：
120.7
作者：
Dominici, F;Peng, RD;Samet, JM
通讯作者：
Samet, JM