An expanding universe of circadian networks in higher plants.

An expanding universe of circadian networks in higher plants.
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DOI:
10.1016/j.tplants.2010.03.003
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发表时间:
2010-05
影响因子:
20.5
通讯作者:
Kay, Steve A.
Kay, Steve A.
中科院分区:
生物学1区
文献类型:
--
作者:
Pruneda-Paz, Jose L.;Kay, Steve A.

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广泛的生物钟网络调节着植物中几乎所有的生物过程。生物钟控制的生理反应与环境条件的每日振荡相结合,从而增强了健康和生长活力。核心时钟组件及其相关分子相互作用的识别建立了植物时钟的基本网络架构,该架构由多个互锁的反馈循环组成。转录反馈的层次结构与受调节的蛋白质周转重叠,设定时钟的步伐,并最终驱动所有时钟控制的过程。虽然最初被描述为线性实体,但越来越多的证据表明,许多信号通路可以在整个网络中充当输入和输出。未来的研究将确定参与这些复杂的调控环的分子机制。
Extensive circadian clock networks regulate almost every biological process in plants. Clock-controlled physiological responses are coupled with daily oscillations in environmental conditions resulting in enhanced fitness and growth vigor. Identification of core clock components and their associated molecular interactions has established the basic network architecture of plant clocks, which consists of multiple interlocked feedback loops. A hierarchical structure of transcriptional feedback overlaid with regulated protein turnover sets the pace of the clock and ultimately drives all clock-controlled processes. While originally described as linear entities, increasing evidence suggests that many signaling pathways can act as both inputs and outputs within the overall network. Future studies will determine the molecular mechanisms involved in these complex regulatory loops.
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