Nanocomposites based on nanoceria regulate the immune microenvironment for the treatment of polycystic ovary syndrome.
Nanocomposites based on nanoceria regulate the immune microenvironment for the treatment of polycystic ovary syndrome.
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基于纳米粒子的纳米复合材料调节免疫微环境治疗多囊卵巢综合征
DOI：
10.1186/s12951-023-02182-w
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发表时间：
2023-11-07
影响因子：
10.2
通讯作者：
Yang, Jing
中科院分区：
文献类型：
--
作者：
Yan, Sisi;Gao, Zhipeng;Ding, Jinli;Chen, Suming;Wang, Zehao;Jin, Wenyi;Qu, Bing;Zhang, Yi;Yang, Lian;Guo, Duanying;Yin, Tailang;Yang, Yanbing;Zhang, Yan;Yang, Jing
免疫系统与多囊卵巢综合征（PCOS）的发病密切相关。巨噬细胞是卵巢促炎微环境中重要的免疫细胞类型之一，在PCOS期间主要通过M2表型极化改善炎症状态。目前的治疗方法缺乏疗效和免疫调节能力，需要一种新的治疗方法来预防炎症和缓解PCOS。本研究中，具有强大抗氧化能力的八面体纳米粒纳米颗粒与抗炎药物白藜芦醇（CeO2@RSV）结合，这表明了一种涉及抗炎和抗氧化功效的关键策略，从而促进PCOS期间颗粒细胞的增殖。值得注意的是，我们的纳米颗粒在脱氢表雄酮（DHEA）诱导的PCOS小鼠模型中具有抗炎活性，有效缓解内分泌功能障碍，炎症和卵巢损伤，具有强大的治疗功效。总之，本研究揭示了新开发的纳米颗粒在改善促炎微环境和促进颗粒细胞功能方面的巨大潜力，代表了利用CeO2@RSV纳米颗粒治疗多囊卵巢综合征的首次尝试，并为临床治疗多囊卵巢综合征提供了新的见解。在线版本包含补充材料，可在10.1186/s12951-023-02182-w获得。
The immune system is closely associated with the pathogenesis of polycystic ovary syndrome (PCOS). Macrophages are one of the important immune cell types in the ovarian proinflammatory microenvironment, and ameliorate the inflammatory status mainly through M2 phenotype polarization during PCOS. Current therapeutic approaches lack efficacy and immunomodulatory capacity, and a new therapeutic method is needed to prevent inflammation and alleviate PCOS. Here, octahedral nanoceria nanoparticles with powerful antioxidative ability were bonded to the anti-inflammatory drug resveratrol (CeO2@RSV), which demonstrates a crucial strategy that involves anti-inflammatory and antioxidative efficacy, thereby facilitating the proliferation of granulosa cells during PCOS. Notably, our nanoparticles were demonstrated to possess potent therapeutic efficacy via anti-inflammatory activities and effectively alleviated endocrine dysfunction, inflammation and ovarian injury in a dehydroepiandrosterone (DHEA)-induced PCOS mouse model. Collectively, this study revealed the tremendous potential of the newly developed nanoparticles in ameliorating the proinflammatory microenvironment and promoting the function of granulosa cells, representing the first attempt to treat PCOS by using CeO2@RSV nanoparticles and providing new insights in combating clinical PCOS. The online version contains supplementary material available at 10.1186/s12951-023-02182-w.
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影响因子：
12.4
作者：
Chen, Xuzhuo;Li, Chang;Cao, Xiankun;Jia, Xinlin;Chen, Xinwei;Wang, Zhenqiang;Xu, Weifeng;Dai, Fengrong;Zhang, Shanyong
通讯作者：
Zhang, Shanyong
DOI：
10.1186/1477-7827-10-49
发表时间：
2012-06-29
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Agarwal A;Aponte-Mellado A;Premkumar BJ;Shaman A;Gupta S
通讯作者：
Gupta S
影响因子：
29.4
作者：
Dong, Shuming;Dong, Yushan;Lin, Jun
通讯作者：
Lin, Jun
影响因子：
6.1
作者：
Fauser, BCJM;Chang, J;Lobo, R
通讯作者：
Lobo, R
影响因子：
5.6
作者：
Huang, Jiana;Chen, Peigen;Zhou, Chuanchuan
通讯作者：
Zhou, Chuanchuan