Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.
Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri.
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DOI：
10.1371/journal.pone.0003866
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发表时间：
2008
期刊：
影响因子：
3.7
通讯作者：
Cellerino A
中科院分区：
文献类型：
--
作者：
Terzibasi E;Valenzano DR;Benedetti M;Roncaglia P;Cattaneo A;Domenici L;Cellerino A
一年生鱼类Nothobranchius furzeri的实验室近交系显示出异常短的预期寿命和年龄标记的加速表达。在这项研究中，我们分析了这种短命物种的新野生衍生系。我们的特点圈养生存和年龄相关的性状在F1和F2的后代野生捕捉N。furzeri。野生N. furzeri系在21周龄时表现出脂褐素的表达和神经变性。实验室中的中位寿命为20至23周，最长寿命为25至32周。这些数据表明，快速的年龄依赖性下降和寿命短是这个物种的自然特征。了N. furzeri分布范围与海拔梯度和干燥度梯度重叠。来自更干旱栖息地的鱼类预计在野外的生存时间更短。我们测试了来自半干旱和半湿润栖息地的圈养品系是否在寿命和年龄相关性状的表达方面存在差异。我们检测到这些线之间年龄依赖性认知下降的明显差异和寿命的轻微差异（中位数为16%，最大寿命为15%）。最后，我们观察到较短的寿命和加速表达的年龄相关的标记在近交实验室菌株相比，这些野生衍生的线。由于不同品系的衰老表型差异较大，N. furzeri可以代表一个模型系统，用于研究自然种群中生活史性状的遗传控制。
A laboratory inbred strain of the annual fish Nothobranchius furzeri shows exceptionally short life expectancy and accelerated expression of age markers. In this study, we analyze new wild-derived lines of this short-lived species. We characterized captive survival and age-related traits in F1 and F2 offspring of wild-caught N. furzeri. Wild-derived N. furzeri lines showed expression of lipofuscin and neurodegeneration at age 21 weeks. Median lifespan in the laboratory varied from to 20 to 23 weeks and maximum lifespan from 25 to 32 weeks. These data demonstrate that rapid age-dependent decline and short lifespan are natural characteristics of this species. The N. furzeri distribution range overlaps with gradients in altitude and aridity. Fish from more arid habitats are expected to experience a shorter survival window in the wild. We tested whether captive lines stemming from semi-arid and sub-humid habitats differ in longevity and expression of age-related traits. We detected a clear difference in age-dependent cognitive decline and a slight difference in lifespan (16% for median, 15% for maximum lifespan) between these lines. Finally, we observed shorter lifespan and accelerated expression of age-related markers in the inbred laboratory strain compared to these wild-derived lines. Owing to large differences in aging phenotypes in different lines, N. furzeri could represent a model system for studying the genetic control of life-history traits in natural populations.
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影响因子：
2
作者：
HAMILTON, WD
通讯作者：
HAMILTON, WD
影响因子：
1.9
作者：
ABRAMS, PA
通讯作者：
ABRAMS, PA
DOI：
10.1007/s003600000104
发表时间：
2000-06-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY
影响因子：
--
作者：
Hoback, WW;Podrabsky, JE;Hand, SC
通讯作者：
Hand, SC
DOI：
10.1016/0300-9629(86)90403-2
发表时间：
1986-01-01
影响因子：
2.3
作者：
LEVELS, PJ;GUBBELS, REMB;DENUCE, JM
通讯作者：
DENUCE, JM
影响因子：
2.9
作者：
Schmued, LC;Albertson, C;Slikker, W
通讯作者：
Slikker, W