Hydroxysafflor Yellow A (HSYA) Improves Learning and Memory in Cerebral Ischemia Reperfusion-Injured Rats via Recovering Synaptic Plasticity in the Hippocampus.
Hydroxysafflor Yellow A (HSYA) Improves Learning and Memory in Cerebral Ischemia Reperfusion-Injured Rats via Recovering Synaptic Plasticity in the Hippocampus.
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羟基红花黄 A (HSYA) 通过恢复海马突触可塑性改善脑缺血再灌注损伤大鼠的学习和记忆
DOI：
10.3389/fncel.2018.00371
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发表时间：
2018
影响因子：
5.3
通讯作者：
Cao X
中科院分区：
文献类型：
--
作者：
Yu L;Duan Y;Zhao Z;He W;Xia M;Zhang Q;Cao X
羟基红花黄A（HSYA）是红花植物花的主要活性化学成分，广泛用于中药治疗脑血管和心血管疾病。最近的研究表明HSYA对脑缺血具有神经保护作用，如抗神经元凋亡、抗氧化活性和清除氧自由基等。然而，HSYA是否以及如何对脑缺血再灌注引起的认知障碍具有保护作用仍不清楚。在本研究中，通过使用大脑中动脉闭塞（MCAO）模型，我们发现颈总动脉（CCA）注射8 mg/kg和16 mg/kg HSYA可以改善Morris水迷宫（MWM）和被动回避任务中受损的认知功能，但4 mg/kg HSYA治疗则不能，表明一定浓度的HSYA治疗可以改善MCAO大鼠的认知功能障碍。此外，我们发现 8 mg/kg HSYA 治疗可挽救 MCAO 大鼠海马受损的长时程增强 (LTP)。综上所述，这些结果首次证明HSYA具有保护认知功能和突触可塑性免受脑缺血再灌注损伤的能力，并为HSYA可能成为脑缺血损伤后认知功能障碍恢复的有希望的替代方案提供了新的见解。
Hydroxysafflor yellow A (HSYA) is the major active chemical component of the safflower plant flower, which is widely used in Chinese medicine for cerebrovascular and cardiovascular disease treatment. Recent studies have demonstrated that HSYA exerts neuroprotective effect on cerebral ischemia, such as neuronal anti-apoptosis, antioxidant activity and oxygen free radical-scavenging. However, whether and how HSYA has a protective effect on cognitive impairment induced by cerebral ischemia reperfusion remains elusive. In the present study, by using the middle cerebral artery occlusion (MCAO) model, we found that 8 mg/kg and 16 mg/kg HSYA administration by common carotid artery (CCA) injection improved impaired cognitive function in Morris water maze (MWM) and passive avoidance tasks, but not 4 mg/kg HSYA treatment, suggesting that HSYA treatment in a certain concentration can improve cognitive impairment in MCAO rats. Furthermore, we found that 8 mg/kg HSYA treatment rescued the impaired long-term potentiation (LTP) in hippocampus of MCAO rats. Taken together, these results for the first time demonstrate that HSYA has the capacity to protect cognitive function and synaptic plasticity against cerebral ischemia-reperfusion injury, and provide a new insight that HSYA may be a promising alternative for recovery of cognitive dysfunction after brain ischemic injury.
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影响因子：
--
作者：
Chang SJ;Cherng JH;Wang DH;Yu SP;Liou NH;Hsu ML
通讯作者：
Hsu ML
影响因子：
120.7
作者：
Heuschmann, PU;Kolominsky-Rabas, PL;Berger, K
通讯作者：
Berger, K
影响因子：
8.3
作者：
GARCIA, JH;WAGNER, S;HU, XJ
通讯作者：
HU, XJ
影响因子：
3.1
作者：
Loureiro, Michael;Lecourtier, Lucas;de Vasconcelos, Anne Pereira
通讯作者：
de Vasconcelos, Anne Pereira
影响因子：
3.4
作者：
Li, Fengling;Wu, Xiqing;Niu, Qingliang
通讯作者：
Niu, Qingliang