Cardiac quantitative susceptibility mapping (QSM) for heart chamber oxygenation.
Cardiac quantitative susceptibility mapping (QSM) for heart chamber oxygenation.
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DOI：
10.1002/mrm.26808
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发表时间：
2018-03
影响因子：
3.3
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Wen Y;Nguyen TD;Liu Z;Spincemaille P;Zhou D;Dimov A;Kee Y;Deh K;Kim J;Weinsaft JW;Wang Y
为了证明在心脏MRI中进行体内定量敏感性制图（QSM）的可行性，并表明使用QSM可以无创地测量混合静脉氧饱和度（SvO2）。在1.5T时采集14名健康志愿者连续屏气时的ecg门控多回波二维梯度回波数据。使用基于图切割的相分析和IDEAL迭代方法去除相包裹和脂肪化学位移。利用偶极子场反演中的预处理方法，解决了从肺部空气到心脏血液的大敏感范围。根据右心室（RV）和左心室（LV）血液敏感性的差异计算SvO2。心脏QSM质量由两名独立读者评估。14名志愿者中有9名（64%）产生了可解释的心脏QSM。QSM图谱显示左、右血有明显的差异，左血敏感性值较高（291.5±32.4 ppb），对应78.3±2.3% SvO2。体内心脏QSM是可行的，可用于测量SvO2，但需要改进数据采集。
To demonstrate the feasibility of in vivo quantitative susceptibility mapping (QSM) in cardiac MRI, and to show that mixed-venous oxygen saturation (SvO2) can be measured non-invasively using QSM. ECG-gated multi-echo 2D gradient echo data were collected at 1.5T from 14 healthy volunteers during successive breath-holds. Phase wraps and fat chemical shift were removed using a graph-cut based phase analysis and IDEAL in an iterative approach. The large susceptibility range from air in the lungs to blood in the heart was addressed by using the preconditioning approach in the dipole field inversion. SvO2 was calculated based on the difference in blood susceptibility between the right ventricle (RV) and left ventricle (LV). Cardiac QSM quality was assessed by two independent readers. Nine out of fourteen volunteers (64%) yielded interpretable cardiac QSM. QSM maps showed strong differential contrast between RV and LV blood with RV blood having higher susceptibility values (291.5 ± 32.4 ppb), which correspond to 78.3 ± 2.3% SvO2. In vivo cardiac QSM is feasible and can be used to measure SvO2, but improvements in data acquisition are needed.
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影响因子：
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