Acute respiratory distress syndrome: is it underrecognized in the pediatric intensive care unit?
Acute respiratory distress syndrome: is it underrecognized in the pediatric intensive care unit?
复制标题
急性呼吸窘迫综合征：在小儿重症监护病房中识别不明吗？
DOI：
10.1007/s00134-008-1029-4
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发表时间：
2008-04
影响因子：
38.9
通讯作者：
Plötz FB
中科院分区：
文献类型：
--
作者：
Kneyber MC;Brouwers AG;Caris JA;Chedamni S;Plötz FB
描述机械通气儿童急性呼吸窘迫综合征（ARDS）的发病率，并研究ARDS在该患者人群中是否未被充分认识。在荷兰两个省的单中心病床儿科重症监护病房进行的回顾性观察性研究。533例0-16岁的机械通气儿童，均符合北美欧洲共识会议的ARDS标准。通过胸片筛选双侧浸润的新情况，在双侧浸润患者中，通过两次单独的连续测量计算PaO 2/FIO 2比值。如果低于200，则将患者归类为患有ARDS。超声心动图排除了左心室功能障碍。发病率的计算方法是获得本地区0-16岁儿童的人数。对于每例患者，记录患者目前是否被认为患有ARDS。41例患者（7.7%）符合ARDS标准，发病率为2.2/100，000/年。死亡率为20.4%。原发性ARDS 30例（73.1%），以病毒性下呼吸道疾病为主。目前仅有10名患者（24.4%）患有ARDS。与成人ARDS相比，儿童ARDS的发生率较低，并且由于大多数患者是由其基础疾病诊断的，因此被进一步低估。
To describe the incidence of acute respiratory distress syndrome (ARDS) in mechanically ventilated children and to study whether ARDS is underrecognized in this patient population. Retrospective observational study in a single-center bed pediatric intensive care unit serving two Dutch provinces. 533 mechanically ventilated children aged 0–16 years, all of whom met the North-American European Consensus Conference criteria for ARDS. Chest radiographs were screened for the novel presence of bilateral infiltrates, in patients with bilateral infiltrates the PaO2/FIO2 ratio was calculated on two separate consecutive measurements. If below 200, the patient was classified as having ARDS. Left ventricular dysfunction was ruled out by echocardiography. The incidence was calculated by obtaining the number of children aged 0–16 years in our region. For each patient it was noted whether the patient was currently considered to have ARDS. Forty-one patients (7.7%) met the criteria for ARDS, with an incidence of 2.2 per 100,000 per year. The mortality rate was 20.4%. Thirty patients (73.1%) had primary ARDS, mainly from viral lower respiratory tract disease. Only ten patients (24.4%) currently had ARDS. The incidence of pediatric ARDS is low compared to that of adult ARDS, and further underestimated as most patients were diagnosed by their underlying diseases.
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DOI：
10.1164/rccm.200210-1175oc
发表时间：
2003-05-15
影响因子：
24.7
作者：
Randolph, AG;Meert, KL;Cheifetz, IM
通讯作者：
Cheifetz, IM
DOI：
10.1164/rccm.200404-544oc
发表时间：
2005-05-01
影响因子：
24.7
作者：
Flori, HR;Glidden, DV;Matthay, MA
通讯作者：
Matthay, MA
影响因子：
8.8
作者：
Bindl, L;Dresbach, K;Lentze, MJ
通讯作者：
Lentze, MJ
影响因子：
24.3
作者：
Dahlem, P;van Aalderen, WMC;Bos, AP
通讯作者：
Bos, AP
影响因子：
9.6
作者：
Rubenfeld, Gordon D.;Herridge, Margaret S.
通讯作者：
Herridge, Margaret S.