High-Expressed Macrophage Scavenger Receptor 1 Predicts Severity Clinical Outcome in Transplant Patient in Idiopathic Pulmonary Fibrosis Disease.
High-Expressed Macrophage Scavenger Receptor 1 Predicts Severity Clinical Outcome in Transplant Patient in Idiopathic Pulmonary Fibrosis Disease.
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DOI：
10.1155/2021/6690100
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发表时间：
2021
影响因子：
4.1
通讯作者：
Ji Y
中科院分区：
文献类型：
--
作者：
Zheng M;Tian T;Liang J;Ye S;Chen J;Ji Y
肺移植已在世界范围内进行，并被认为是治疗各种终末期肺部疾病的有效方法。然而，鉴别肺移植受者同种异体移植衰竭高危患者的可靠临床指标有限。近年来对肺部疾病免疫学方面的研究进展表明，先天巨噬细胞活化是由病原体或病原体衍生分子诱导的，这是肺部炎症和纤维化发病机制的重要证据。本研究旨在评价CD86-和巨噬细胞清道夫受体1- (MSR1-)阳性细胞在特发性肺纤维化（IPF）和肺动脉高压（PAH）发生过程中的临床意义，并探讨其在肺移植后预后预测中的潜在作用。对2015年12月至2016年12月无锡市人民医院心胸外科37例IPF和15例PAH患者肺移植组织进行免疫组化（IHC）分析，检测肺移植后CD86和MSR1的表达及与临床事件的相关性。免疫组化结果显示，IPF患者肺组织中MSR1、IL-13和arginase-1 （Arg1）的表达明显高于PAH患者，而CD86的表达不显著。吸烟的IPF患者肺组织中MSR1、IL-13、Arg1的表达明显高于不吸烟的IPF患者，CD86的表达不明显。此外，感染肺炎克雷伯菌的IPF患者中msr1阳性细胞的表达明显高于未感染的患者。msr1阳性巨噬细胞与FEV1和FVC呈负相关，但与TLC和TLCO无相关性。然而，cd86阳性巨噬细胞与上述肺功能相关因素无显著相关性。此外，MSR1诊断IPF的ROC曲线下面积（AUC）高于CD86。生存分析表明，高水平的msr1阳性巨噬细胞对肺移植IPF患者的预后影响较差。本研究提示肺炎克雷伯菌感染相关msr1阳性细胞在IPF进展中的临床意义，可作为肺移植后IPF的预后指标；降低IPF中msr1阳性巨噬细胞表达的发展策略可能对肺移植有益。
Lung transplantation has been performed worldwide and admitted as an effective treatment for patients with various end-stage lung diseases. However, limit reliable clinical indicators exist to identify patients at high risk for allograft failure in lung transplant recipients. The recent advances in the knowledge of immunological aspects of the pulmonary diseases, for that innate macrophage activation, are induced by pathogen or pathogen-derived molecules and widely accepted as the critical evidence among the pathogenesis of lung inflammation and fibrosis. This study was aimed at evaluating the clinical significance of CD86- and macrophage scavenger receptor 1- (MSR1-) positive cells during the development of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH), and their potential roles in the prediction of the outcomes after lung transplantation were examined. Tissues from lung transplantation for 37 IPF and 15 PAH patients from the Department of Cardiothoracic Surgery in Wuxi People's Hospital from December 2015 to December 2016 were analyzed by immunohistochemistry (IHC) for detecting the expression and CD86 and MSR1 and correlated with clinical events after lung transplantation. IHC results showed that the expression of MSR1, IL-13, and arginase-1 (Arg1) but not CD86 in the lung section of IPF patients was dramatically enhanced when compared with that of PAH patients. The expression of MSR1, IL-13, and Arg1 but not CD86 in the lung from IPF patients with smoking was significantly increased when compared with that from nonsmoking subjects. In addition, the expression of MSR1-positive cells in IPF subjects with Klebsiella pneumoniae infection was dramatically enhanced than that in noninfection subjects. MSR1-positive macrophages were negatively associated with FEV1 and with FVC but not associated with TLC and with TLCO. However, CD86-positive macrophages were not significantly associated with the above lung function-related factors. Furthermore, MSR1 had a higher area under the ROC curve (AUC) than CD86 for IPF diagnosis. Survival analysis indicated that high levels of MSR1-positive macrophages had a worse prognostic effect for IPF patients with lung transplantation. Our study indicates the clinical significance of Klebsiella pneumoniae infection-related MSR1-positive cells in IPF progression, and it could be a prognostic marker in IPF after the lung transplant; development strategies to reduce the expression of MSR1-positive macrophages in IPF may be beneficial for the lung transplant.
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影响因子：
5.4
作者：
Barron, Luke;Wynn, Thomas A.
通讯作者：
Wynn, Thomas A.
影响因子：
5.5
作者：
Gharib, Sina A.;Johnston, Laura K.;Manicone, Anne M.
通讯作者：
Manicone, Anne M.
影响因子：
2.8
作者：
Arora S;Dev K;Agarwal B;Das P;Syed MA
通讯作者：
Syed MA
巨噬细胞介导的炎症和疾病：关注肺部。
影响因子：
4.6
作者：
Gwyer Findlay E;Hussell T
通讯作者：
Hussell T
影响因子：
14.2
作者：
Li, Dong;Guabiraba, Rodrigo;Besnard, Anne-Gaelle;Komai-Koma, Mousa;Jabir, Majid S.;Zhang, Li;Graham, Gerard J.;Kurowska-Stolarska, Mariola;Liew, Foo Y.;McSharry, Charles;Xu, Damo
通讯作者：
Xu, Damo