IL-34 is associated with the presence and severity of renal dysfunction and coronary artery disease in patients with heart failure.
IL-34 is associated with the presence and severity of renal dysfunction and coronary artery disease in patients with heart failure.
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IL-34 与心力衰竭患者肾功能障碍和冠状动脉疾病的存在及其严重程度相关。
DOI：
10.1038/srep39324
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发表时间：
2016-12-16
影响因子：
4.6
通讯作者：
Tao R
中科院分区：
文献类型：
--
作者：
Fan Q;Yan X;Zhang H;Lu L;Zhang Q;Wang F;Xi R;Hu J;Chen Q;Niu W;Shen W;Zhang R;Tao R
在心力衰竭（HF）患者中鉴定出促炎介质，其中一些可用作具有诊断或预后价值的生物标志物。白细胞介素-34（IL-34）作为集落刺激因子-1受体（CSF-1 R）的另一个配体，已被鉴定为参与慢性心力衰竭（CHF）的促炎细胞因子。然而，IL-34在CHF并发症中的潜在影响仍然未知。为探讨CHF患者血清IL-34水平的临床意义，对510例CHF患者进行了血清IL-34水平测定。目前的研究表明，CHF患者血清IL-34水平升高与肾功能较差和严重贫血相关。在校正年龄、性别、常规风险因素和其他显著协变量后，在多变量线性和逻辑回归分析中，IL-34与肾功能不全的存在和严重程度（通过eGFR和胱抑素C测量）呈正相关。IL-34也被证明是HF患者中CAD的独立危险因素。总之，血清IL-34水平升高与CHF患者的肾功能不全和CAD独立相关，与收缩功能无关。
Pro-inflammatory mediators are identified in patients with heart failure (HF), some of which may be used as biomarkers with diagnostic or prognostic value. As an additional ligand of Colony Stimulating Factor-1 Receptor (CSF-1R), interleukin-34 (IL-34) has been identified as a pro-inflammatory cytokine participating in chronic heart failure (CHF). However, the potential impact of IL-34 in CHF complications remains unknown. In order to determine the clinical significance of serum IL-34 in CHF patients, especially those with kidney dysfunction and coronary artery disease (CAD) comorbid conditions, serum IL-34 was measured in 510 consecutive patients with CHF in a cross-sectional study. The present study demonstrated that higher serum IL-34 levels were associated with poorer renal function and more severe anemia in patients with CHF. After adjusting for age, gender, conventional risk factors, and other significant covariates, IL-34 positively correlated with the presence and severity of renal dysfunction (as measured by eGFR and cystatin C) on multivariable linear and logistic regression analysis. IL-34 was also demonstrated to be an independent risk factor for CAD among HF patients. In conclusion, elevated serum IL-34 levels were demonstrated to be independently associated with renal insufficiency and CAD in patients with CHF, regardless of the systolic function.
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影响因子：
1.6
作者：
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通讯作者：
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Lupon, Josep
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2.6
作者：
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Waz, Piotr