Mesolimbic recruitment by nondrug rewards in detoxified alcoholics: effort anticipation, reward anticipation, and reward delivery.
Mesolimbic recruitment by nondrug rewards in detoxified alcoholics: effort anticipation, reward anticipation, and reward delivery.
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DOI：
10.1002/hbm.21351
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发表时间：
2012-09
影响因子：
4.8
通讯作者：
Hommer, Daniel W.
中科院分区：
文献类型：
--
作者：
Bjork, James M.;Smith, Ashley R.;Chen, Gang;Hommer, Daniel W.
关键词：
激励神经回路对非药物奖励的异常敏感性已被认为是药物成瘾的危险因素或后果。使用功能磁共振成像，我们测试了酒精依赖患者(ADP：n=29)与对照组(n=23)相比，腹侧纹状体(VS)激励神经回路的招募是否发生了变化：1)提示对金钱奖励的反应，2)反应后对奖励的预期，或3)奖励的提供。使用两阶段呈现奖励预测信息的工具性任务，受试者看到暗示有机会因回应目标而赢得0美元、1美元或10美元。在这个反应之后，受试者被告知他们的成功是否会通过词汇通知(“Hit？”)来表示。或者通过提供金钱奖励(“赢了？”)。在一段可变的时间间隔后，受试者随后查看试验结果。我们发现，在任务对比的体素激活或从VS提取的信号变化方面，没有显著的组间差异。ADP和对照组均通过反应前奖赏预期表现出显著的VS和其他边缘招募。此外，控制组也表现为反应后奖赏预期的VS招募，而ADP有明显的亚阈值VS激活。这两组人对奖励递送也表现出类似的中脑边缘反应。在所有受试者中，问卷测量的“火热”冲动与通过低回报的后反应预期的VS招募和通过提供低回报的VS招募相关。这些发现表明，在戒酒患者中，对非药物奖励的激励-动机加工基本上保持不变，奖励引发的与招募相比，更多地与个体特征冲动的差异相关，而不是成瘾。
Aberrant sensitivity of incentive neurocircuitry to nondrug rewards has been suggested as either a risk factor for or consequence of drug addiction. Using functional magnetic resonance imaging, we tested whether alcohol-dependent patients (ADP: n = 29) showed altered recruitment of ventral striatal (VS) incentive neurocircuitry compared to controls (n = 23) by: 1) cues to respond for monetary rewards, 2) post-response anticipation of rewards, or 3) delivery of rewards. Using an instrumental task with two-stage presentation of reward-predictive information, subjects saw cues signaling opportunities to win $0, $1, or $10 for responding to a target. Following this response, subjects were notified whether their success would be indicated by a lexical notification (“Hit?”) or by delivery of a monetary reward (“Win?”). After a variable interval, subjects then viewed the trial outcome. We found no significant group differences in voxelwise activation by task contrasts, or in signal change extracted from VS. Both ADP and controls showed significant VS and other limbic recruitment by pre-response reward anticipation. In addition, controls also showed VS recruitment by post-response reward-anticipation, and ADP had appreciable subthreshold VS activation. Both groups also showed similar mesolimbic responses to reward deliveries. Across all subjects, a questionnaire measure of “hot” impulsivity correlated with VS recruitment by post-response anticipation of low rewards and with VS recruitment by delivery of low rewards. These findings indicate that incentive-motivational processing of nondrug rewards is substantially maintained in recovering alcoholics, and that reward-elicited VS recruitment correlates more with individual differences in trait impulsivity irrespective of addiction.
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影响因子：
5.7
作者：
Knutson, B;Fong, GW;Homme, D
通讯作者：
Homme, D
影响因子：
5.3
作者：
Bjork, JM;Knutson, B;Hommer, DW
通讯作者：
Hommer, DW
影响因子：
6.1
作者：
KAHNEMAN, D;TVERSKY, A
通讯作者：
TVERSKY, A
影响因子：
4.2
作者：
Gazdzinski, S;Durazzo, TC;Meyerhoff, DJ
通讯作者：
Meyerhoff, DJ
影响因子：
10.6
作者：
Beck, Anne;Schlagenhauf, Florian;Wrase, Jana
通讯作者：
Wrase, Jana