Measuring the strength of mice.
Measuring the strength of mice.
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DOI：
10.3791/2610
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发表时间：
2013-06-02
期刊：
影响因子：
--
通讯作者：
Deacon RM
中科院分区：
文献类型：
--
作者：
Deacon RM
Kondziela设计了倒屏测试，并于1964年发表。这是一个测试肌肉力量使用所有四肢。大多数正常小鼠在这项任务中很容易得分最高;这是一个快速但不敏感的总屏幕，本文中描述的重量测试将提供更好的肌肉力量测量。也有几个基于应变片的仪器可用于商业，将提供更多的分级数据比倒置屏幕测试，但它们的成本可能使他们超出了许多实验室，不专门从事强度测试。因此，在2000年，作者设计了一种廉价而简单的装置。它由一系列不断增加长度的链环组成，连接到一个“毛皮收集器”上，毛皮收集器是一个细钢丝网球，用于防止硬水地区的水垢堆积。一次偶然的观察发现，老鼠可以紧紧地抓住这些东西，所以它们被证明是举重器械的理想抓点。商业力量计的一个常见缺陷是杆或其他抓握特征不够薄，小鼠无法发挥最大抓握力。一般来说，金属丝或金属条越细，老鼠的小爪子就能抓得越紧。这是一个纯粹的力量测试，尽管对于任何测试来说，动机因素都可能发挥作用。然而，使用鳞片收集器似乎可以最大限度地减少动机问题，因为对于大多数正常的年轻成年小鼠来说，动机似乎非常高。
Kondziela7 devised the inverted screen test and published it in 1964. It is a test of muscle strength using all four limbs. Most normal mice easily score maximum on this task; it is a quick but insensitive gross screen, and the weights test described in this article will provide a finer measure of muscular strength. There are also several strain gauge-based pieces of apparatus available commercially that will provide more graded data than the inverted screen test, but their cost may put them beyond the reach of many laboratories which do not specialize in strength testing. Hence in 2000 a cheap and simple apparatus was devised by the author. It consists of a series of chain links of increasing length, attached to a "fur collector" a ball of fine wire mesh sold for preventing limescale build up in hard water areas. An accidental observation revealed that mice could grip these very tightly, so they proved ideal as a grip point for a weight-lifting apparatus. A common fault with commercial strength meters is that the bar or other grip feature is not thin enough for mice to exert a maximum grip. As a general rule, the thinner the wire or bar, the better a mouse can grip with its small claws. This is a pure test of strength, although as for any test motivational factors could potentially play a role. The use of scale collectors, however, seems to minimize motivational problems as the motivation appears to be very high for most normal young adult mice.
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影响因子：
2.9
作者：
Deacon, RMJ;Brook, RC;Liss, B
通讯作者：
Liss, B
影响因子：
3.4
作者：
Guenther, K;Deacon, RMJ;Rawlins, JNP
通讯作者：
Rawlins, JNP
影响因子：
2.7
作者：
Deacon, R. M. J.;Thomas, C. L.;Morley, B. J.
通讯作者：
Morley, B. J.
影响因子：
2.7
作者：
Deacon, RMJ;Croucher, A;Rawlins, JNP
通讯作者：
Rawlins, JNP
DOI：
10.1073/pnas.81.4.1189
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BULFIELD, G;SILLER, WG;MOORE, KJ
通讯作者：
MOORE, KJ