Longitudinal course of behavioural and psychological symptoms of dementia: systematic review.
Longitudinal course of behavioural and psychological symptoms of dementia: systematic review.
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DOI：
10.1192/bjp.bp.114.148403
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Brayne C
中科院分区：
文献类型：
--
作者：
van der Linde RM;Dening T;Stephan BC;Prina AM;Evans E;Brayne C
背景：需要更多关于痴呆症过程中行为和心理症状(BPSD)模式的信息，以告知患者和临床医生并设计未来的干预措施。旨在确定BPSD的持久性和发病率及其与认知功能的关系，在痴呆症患者中或在调查痴呆症发病的队列中。方法采用系统的文献复习方法，对11种症状的基线患病率、持久性和发生率进行分析。审查是根据既定的指导方针进行的，例外的是我们不能排除所审查的研究中存在偏见的可能性。结果纳入的59项研究在目标和方法上表现出相当大的异质性。症状多动、冷漠具有较高的持续性和发生率；抑郁和焦虑表现为中中度持续性和中等发生率；精神病性症状表现为低持续性和中低度发生率。结论尽管不同研究在背景、焦点和随访时间方面存在异质性，但不同BPSD患者的纵向病程在临床上存在相关差异。淡漠是痴呆病程中唯一具有较高基线患病率、持久性和发生率的症状。
Background More information about the pattern of behavioural and psychological symptoms of dementia (BPSD) in the course of dementia is needed to inform patients and clinicians and to design future interventions. Aims To determine the persistence and incidence of BPSD and their relation to cognitive function, in individuals with dementia or in cohorts investigated for dementia onset. Method A systematic literature review analysed the baseline prevalence, persistence and incidence of 11 symptoms. The review was conducted according to established guidelines with the exception that we could not exclude the possibilities of bias in the studies examined. Results The 59 included studies showed considerable heterogeneity in their objectives and methods. The symptoms hyperactivity and apathy showed high persistence and incidence; depression and anxiety low or moderate persistence and moderate incidence; and psychotic symptoms low persistence with moderate or low incidence. Conclusions Despite heterogeneity across studies in terms of setting, focus and length of follow-up, there were clinically relevant differences in the longitudinal courses of different BPSD. Apathy was the only symptom with high baseline prevalence, persistence and incidence during the course of dementia.
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影响因子：
8.1
作者：
de Rooij, Alida H. P. M.;Luijkx, Katrien G.;Schols, Jos M. G. A.
通讯作者：
Schols, Jos M. G. A.
影响因子：
7.2
作者：
Dotson, Vonetta M.;Resnick, Susan M.;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
影响因子：
--
作者：
CHEN, JY;STERN, Y;MAYEUX, R
通讯作者：
MAYEUX, R
影响因子：
4
作者：
Aalten, P;de Vugt, ME;Verhey, FRJ
通讯作者：
Verhey, FRJ
影响因子：
2.1
作者：
Asada, T;Kinoshita, T;Kakuma, T
通讯作者：
Kakuma, T