Roux en Y gastric bypass increases ethanol intake in the rat.
Roux en Y gastric bypass increases ethanol intake in the rat.
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DOI：
10.1007/s11695-013-0884-4
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发表时间：
2013-07
期刊：
影响因子：
2.9
通讯作者：
Benoit, Stephen C.
中科院分区：
文献类型：
--
作者：
Davis, Jon F.;Tracy, Andrea L.;Schurdak, Jennifer D.;Magrisso, Irwin J.;Grayson, Bernadette E.;Seeley, Randy J.;Benoit, Stephen C.
Roux en Y胃分流术(RYGB)是目前治疗肥胖及其相关并发症最有效的治疗方法。除了减轻体重和解决糖尿病等代谢综合征外，据报道，RYGB程序还会增加人类的酒精消耗量。使用近交系啮齿动物模型，我们证明了RYGB增加了手术后的酒精消耗，这种影响不能仅仅用手术后的体重减轻来解释，而且它与手术前的体重或饮食组成无关。酒精代谢的改变和术后Ghrelin释放的变化也无法解释酒精摄入量的变化。进一步研究这种行为效应背后的潜在生理因素发现，RYGB手术后与奖励相关的大脑区域的基因表达模式发生了变化。这些发现具有重要的临床意义，因为它们表明，RYGB手术直接导致不喜欢酒精的大鼠酒精摄入量增加，并诱导大脑回路中调节各种食欲行为的神经生物学变化。
Roux en Y gastric bypass (RYGB) surgery is currently the most effective therapy employed to treat obesity and its associated complications. In addition to weight loss and resolution of metabolic syndromes, such as diabetes, the RYGB procedure has been reported to increase alcohol consumption in humans. Using an outbred rodent model, we demonstrate that RYGB increases postsurgical ethanol consumption, that this effect cannot be explained solely by postsurgical weight loss and that it is independent of presurgical body weight or dietary composition. Altered ethanol metabolism and postsurgical shifts in release of ghrelin were also unable to account for changes in alcohol intake. Further investigation of the potential physiological factors underlying this behavioral effect identified altered patterns of gene expression in brain regions associated with reward following RYGB surgery. These findings have important clinical implications as they demonstrate that RYGB surgery leads directly to increased alcohol intake in otherwise alcohol nonpreferring rat and induces neurobiological changes in brain circuits that mediate a variety of appetitive behaviors.
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影响因子：
2.9
作者：
Carr, KD
通讯作者：
Carr, KD
DOI：
10.1111/j.1530-0277.1998.tb03611.x
发表时间：
1998-02-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Koob, GF;Roberts, AJ;Weiss, F
通讯作者：
Weiss, F
影响因子：
1.7
作者：
Hajnal, A;Norgren, R
通讯作者：
Norgren, R
影响因子：
4.9
作者：
Korner, J.;Inabet, W.;Fabres, G.;Conwell, I. M.;McMahon, D. J.;Salas, R.;Taveras, C.;Schrope, B.;Bessler, M.
通讯作者：
Bessler, M.
影响因子：
56.9
作者：
CARROLL, ME;FRANCE, CP;MEISCH, RA
通讯作者：
MEISCH, RA