Cognitive Dysfunction in Type 2 Diabetes Is Not a One-Way Process: Evidence From a Longitudinal Brain Connectivity Study.
Cognitive Dysfunction in Type 2 Diabetes Is Not a One-Way Process: Evidence From a Longitudinal Brain Connectivity Study.
复制标题
2 型糖尿病的认知功能障碍不是单向过程：来自纵向大脑连接研究的证据
DOI：
10.3389/fendo.2022.874538
复制
发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
认知功能障碍是糖尿病的一种重要合并症，其特征是脑功能连接低下。然而，我们最近的研究表明，年轻 2 型糖尿病患者存在适应性超连接，且认知能力下降。这项纵向研究旨在进一步探讨定期血糖控制后功能连接和认知结果的变化。招募后 18 个月，参与者接受了第二次认知评估和磁共振成像。对先前在基线时确定的三个增强的功能连接进行了跟踪。采用线性混合效应模型来比较 2 型糖尿病患者和非糖尿病对照者认知和功能连接的纵向变化。使用线性回归模型来研究功能连接变化与认知表现变化之间的关联。在糖尿病中观察到多个认知领域的改善；然而，基线时增强的功能连接显着下降。此外，海马连接性的减少与斯特鲁普任务准确性的增加相关，后扣带皮层连接性的减少与糖尿病蒙特利尔认知评估的增加相关。这项研究表明，与糖尿病相关的认知功能障碍不是一个单向过程，大脑连接的早期增强是认知逆转的潜在“窗口期”。
Cognitive dysfunction is an important comorbidity of diabetes characterized by brain functional hypo-connectivity. However, our recent study demonstrated an adaptive hyper-connectivity in young type 2 diabetes with cognitive decrements. This longitudinal study aimed to further explore the changes in functional connectivity and cognitive outcomes after regular glycemic control. At 18 months after recruitment, participants underwent a second cognitive assessment and magnetic resonance imaging. Three enhanced functional connectivities previously identified at baseline were followed up. Linear mixed-effects models were performed to compare the longitudinal changes of cognition and functional connectivity in patients with type 2 diabetes and non-diabetic controls. A linear regression model was used to investigate the association between changes in functional connectivity and changes in cognitive performance. Improvements in multiple cognitive domains were observed in diabetes; however, the enhanced functional connectivity at baseline decreased significantly. Moreover, the decrease in hippocampal connectivity was correlated with an increase in the accuracy of Stroop task and the decrease in posterior cingulate cortex connectivity was correlated with an increase in Montreal Cognitive Assessment in diabetes. This study suggests diabetes-related cognitive dysfunction is not a one-way process and the early-stage enhancement of brain connectivity was a potential “window period” for cognitive reversal.
登录
查看更多内容
影响因子：
48
作者：
Cukierman-Yaffe, Tali;Gerstein, Hertzel C.;Temelkova-Kurktschiev, Theodora
通讯作者：
Temelkova-Kurktschiev, Theodora
鼻内胰岛素增强 2 型糖尿病海马区静息态功能连接
影响因子：
7.7
作者：
Zhang, Hui;Hao, Ying;Novak, Vera
通讯作者：
Novak, Vera
影响因子：
7.7
作者：
Hoogenboom WS;Marder TJ;Flores VL;Huisman S;Eaton HP;Schneiderman JS;Bolo NR;Simonson DC;Jacobson AM;Kubicki M;Shenton ME;Musen G
通讯作者：
Musen G
DPARSF：用于静息态 fMRI“管道”数据分析的 MATLAB 工具箱。
影响因子：
3
作者：
Chao-Gan Y;Yu-Feng Z
通讯作者：
Yu-Feng Z
无轻度认知障碍的 2 型糖尿病患者白质完整性和海马功能连接的改变。
影响因子：
2.9
作者：
Sun Q;Chen GQ;Wang XB;Yu Y;Hu YC;Yan LF;Zhang X;Yang Y;Zhang J;Liu B;Wang CC;Ma Y;Wang W;Han Y;Cui GB
通讯作者：
Cui GB