Alterations of White Matter Integrity and Hippocampal Functional Connectivity in Type 2 Diabetes Without Mild Cognitive Impairment.
Alterations of White Matter Integrity and Hippocampal Functional Connectivity in Type 2 Diabetes Without Mild Cognitive Impairment.
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无轻度认知障碍的 2 型糖尿病患者白质完整性和海马功能连接的改变。
DOI：
10.3389/fnana.2018.00021
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发表时间：
2018
影响因子：
2.9
通讯作者：
Cui GB
中科院分区：
文献类型：
--
作者：
Sun Q;Chen GQ;Wang XB;Yu Y;Hu YC;Yan LF;Zhang X;Yang Y;Zhang J;Liu B;Wang CC;Ma Y;Wang W;Han Y;Cui GB
目的：应用弥散张量成像（DTI）和静息态功能磁共振成像（rs-fMRI）研究无轻度认知功能损害（MCI）的2型糖尿病（T2 DM）患者脑白色完整性和海马功能连接（FC）。方法：选择12例无MCI的T2 DM患者和24例年龄、性别、文化程度相匹配的健康对照者（HC）。在3.0T MR扫描仪上采集DTI和rs-fMRI数据。采用基于束的空间统计学（Tract-based spatial statistics，TBSS）结合感兴趣区（region of interests，ROI）分析研究DTI指标（各向异性分数（fractional anisotropy，FA）、平均扩散系数（mean diffusivity，MD）、λ1和λ23）的变化，并进行FC测量以计算海马与其他脑区的FC。认知功能评定采用简易精神状态检查量表（MMSE）和蒙特利尔认知功能评定量表（莫卡）。还对这些参与者的脑容量进行了评估。结果：两组MMSE和莫卡评分无显著性差异。无MCI的T2 DM患者无全脑或局部脑体积减少。DTI分析显示广泛的WM中断，特别是在胼胝体（CC）的身体。某些大脑结构的海马FC显着减少，尤其是双侧额叶皮质。此外，左侧丘脑后辐射区FA减少和CC压部MD增加与海马FC向尾状核和额叶皮质的减少密切相关。结论：无MCI的T2 DM患者存在广泛的WM破坏和海马FC异常。此外，WM破坏与海马FC异常密切相关。无MCI的T2 DM患者脑体积无明显减少。2型糖尿病患者的DTI分析显示广泛的白色物质破坏，尤其是胼胝体内。尽管T2 DM患者没有MCI，但检测到海马区与某些关键脑区之间的功能连接减少。2型糖尿病患者海马功能连接的改变与白色结构的改变密切相关。本试验注册于ClinicalTrials.gov（NCT 02420470，https：//www.clinicaltrials.gov/）。
Aims: To investigate the white matter (WM) integrity and hippocampal functional connectivity (FC) in type 2 diabetes mellitus (T2DM) patients without mild cognitive impairment (MCI) by using diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI), respectively. Methods: Twelve T2DM patients without MCI and 24 age, sex and education matched healthy controls (HC) were recruited. DTI and rs-fMRI data were subsequently acquired on a 3.0T MR scanner. Tract-based spatial statistics (TBSS) combining region of interests (ROIs) analysis was used to investigate the alterations of DTI metrics (fractional anisotropy (FA), mean diffusivity (MD), λ1 and λ23) and FC measurement was performed to calculate hippocampal FC with other brain regions. Cognitive function was evaluated by using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Brain volumes were also evaluated among these participants. Results: There were no difference of MMSE and MoCA scores between two groups. Neither whole brain nor regional brain volume decrease was revealed in T2DM patients without MCI. DTI analysis revealed extensive WM disruptions, especially in the body of corpus callosum (CC). Significant decreases of hippocampal FC with certain brain structures were revealed, especially with the bilateral frontal cortex. Furthermore, the decreased FA in left posterior thalamic radiation (PTR) and increased MD in the splenium of CC were closely related with the decreased hippocampal FC to caudate nucleus and frontal cortex. Conclusions: T2DM patients without MCI showed extensive WM disruptions and abnormal hippocampal FC. Moreover, the WM disruptions and abnormal hippocampal FC were closely associated. T2DM patients without MCI demonstrated no obvious brain volume decrease. Extensive white matter disruptions, especially within the body of corpus callosum, were revealed with DTI analysis among the T2DM patients. Despite no MCI in T2DM patients, decreased functional connectivity between hippocampal region and some critical brain regions were detected. The alterations in hippocampal functional connectivity were closely associated with those of the white matter structures in T2DM patients. Highlights This trial was registered to ClinicalTrials.gov (NCT02420470, https://www.clinicaltrials.gov/).
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影响因子：
7.7
作者：
Musen G;Jacobson AM;Bolo NR;Simonson DC;Shenton ME;McCartney RL;Flores VL;Hoogenboom WS
通讯作者：
Hoogenboom WS
影响因子：
7.7
作者：
Hoogenboom WS;Marder TJ;Flores VL;Huisman S;Eaton HP;Schneiderman JS;Bolo NR;Simonson DC;Jacobson AM;Kubicki M;Shenton ME;Musen G
通讯作者：
Musen G
影响因子：
3.3
作者：
Mayeda ER;Whitmer RA;Yaffe K
通讯作者：
Yaffe K
静止状态功能性MRI：非塞特人一直想知道的一切。
DOI：
10.3174/ajnr.a5527
发表时间：
2018-08
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Lv H;Wang Z;Tong E;Williams LM;Zaharchuk G;Zeineh M;Goldstein-Piekarski AN;Ball TM;Liao C;Wintermark M
通讯作者：
Wintermark M
影响因子：
5.1
作者：
Hayashi, Kumi;Kurioka, Soichi;Sugimoto, Toshitsugu
通讯作者：
Sugimoto, Toshitsugu