MicroRNA and cancer--focus on apoptosis.
MicroRNA and cancer--focus on apoptosis.
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DOI：
10.1111/j.1582-4934.2008.00510.x
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发表时间：
2009-01
影响因子：
5.3
通讯作者：
Lee CG
中科院分区：
文献类型：
--
作者：
Wang Y;Lee CG
microRNA（miRs）是一类在转录后和/或翻译水平调控基因表达的非编码小RNA。miR在多种生物学过程中发挥重要作用，包括发育、细胞分化、增殖和凋亡。最近的证据表明，miR基因座经常映射到癌症相关的基因组区域，并且失调的miR表达谱与许多癌症类型相关，暗示miR参与导致肿瘤发生的关键过程。在这里，我们回顾了目前的研究结果miRs和肿瘤发生，重点是他们参与细胞凋亡途径。一个重要的观察结果是，据报道，超过四分之一的所有已知的人类miR在至少一种癌症类型中被失调。发现miR的一个子集（例如miR-21和miR-155）的表达一致上调，而miR的另一个子集（例如miR-143和miR-145）在不同的癌症类型中一致下调，表明它们参与调节其失调可能导致肿瘤发生的常见细胞过程。几种miR涉及在细胞增殖和凋亡中发挥作用。一些miR，如miR-29 b和miR-15-16，仅影响凋亡途径，而其他miR，包括let-7/miR-98和miR-17-92，可能在凋亡和细胞增殖途径中发挥作用。总之，虽然我们目前对miR的功能的理解仍然是零碎的，但结合起来，这篇综述强调了miR在细胞过程调节中发挥的复杂和错综复杂的作用。因此，miR表达的扰动可能导致肿瘤发生。
MicroRNAs (miRs) are small non-coding RNAs regulating gene expression at the post-transcriptional and/or translational levels. miRs play important roles in diverse biological processes, including development, cell differentiation, proliferation and apoptosis. Recent evidence has shown that miR loci frequently map to cancer-associated genomic regions and deregulated miR expression profiles are associated with many cancer types, implicating miRs in crucial processes that lead to tumourigenesis. Here, we review the current findings about miRs and tumourigenesis, focusing on their involvement in the apoptosis pathway. A significant observation is that greater than one-quarter of all known human miRs were reported to be deregulated in at least one cancer type. The expression of a subset of miRs (e.g. miR-21 and miR-155) was found to be consistently up-regulated, whereas another subset of miRs (e.g.miR-143 and miR-145) was consistently down-regulated across different cancer types suggesting their involvement in regulating common cellular processes whose deregulation may lead to tumourigenesis. Several miRs were implicated to play roles in cell proliferation and apoptosis. Some miRs, such as miR-29b and miR-15–16, influence only the apoptotic pathway, whereas others including let-7/miR-98 and miR-17–92 may play roles in both the apoptotic and cell-proliferation pathways. In conclusion, although our current understanding of the functions of miRs is still fragmentary, taken together, this review highlights the complex and intricate roles that miRs play in the regulation of cellular processes. Perturbation of the expression of miRs may thus lead to tumourigenesis.
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影响因子：
4.5
作者：
Christoffersen, Nanna Ronbjerg;Silahtaroglu, Asli;Lund, Anders H.
通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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作者：
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