Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment.

Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment.
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纳米技术促进的基于细菌的药物和基因递送系统用于癌症治疗的最新进展。

DOI:
10.3390/pharmaceutics13070940
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发表时间:
2021-06-24
期刊:
影响因子:
5.4
通讯作者:
Wang Q
Wang Q
中科院分区:
医学2区
文献类型:
--
作者:
Zhu C;Ji Z;Ma J;Ding Z;Shen J;Wang Q

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Cancer is one of the most devastating and ubiquitous human diseases. Conventional therapies like chemotherapy and radiotherapy are the most widely used cancer treatments. Despite the notable therapeutic improvements that these measures achieve, disappointing therapeutic outcome and cancer reoccurrence commonly following these therapies demonstrate the need for better alternatives. Among them, bacterial therapy has proven to be effective in its intrinsic cancer targeting ability and various therapeutic mechanisms that can be further bolstered by nanotechnology. In this review, we will discuss recent advances of nanotechnology-facilitated bacteria-based drug and gene delivery systems in cancer treatment. Therapeutic mechanisms of these hybrid nanoformulations are highlighted to provide an up-to-date understanding of this emerging field.
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